node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AXDND1 | UMODL1 | ENSP00000356590 | ENSP00000386126 | Axonemal dynein light chain domain containing 1. | Uromodulin like 1. | 0.492 |
FAM13C | MSLNL | ENSP00000481854 | ENSP00000441381 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | 0.429 |
FAM13C | UMODL1 | ENSP00000481854 | ENSP00000386126 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Uromodulin like 1. | 0.471 |
HSF2BP | LIPI | ENSP00000291560 | ENSP00000343331 | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Belongs to the AB hydrolase superfamily. Lipase family. | 0.446 |
HSF2BP | UMODL1 | ENSP00000291560 | ENSP00000386126 | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | Uromodulin like 1. | 0.488 |
KRTAP10-10 | UMODL1 | ENSP00000369438 | ENSP00000386126 | Keratin-associated protein 10-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | Uromodulin like 1. | 0.471 |
LIPI | HSF2BP | ENSP00000343331 | ENSP00000291560 | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Belongs to the AB hydrolase superfamily. Lipase family. | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | 0.446 |
LIPI | PRMT2 | ENSP00000343331 | ENSP00000380759 | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Belongs to the AB hydrolase superfamily. Lipase family. | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)- mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. | 0.402 |
LIPI | UMODL1 | ENSP00000343331 | ENSP00000386126 | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Belongs to the AB hydrolase superfamily. Lipase family. | Uromodulin like 1. | 0.545 |
MSLNL | FAM13C | ENSP00000441381 | ENSP00000481854 | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 0.429 |
MSLNL | UMODL1 | ENSP00000441381 | ENSP00000386126 | Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family. | Uromodulin like 1. | 0.507 |
PRMT2 | LIPI | ENSP00000380759 | ENSP00000343331 | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)- mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Belongs to the AB hydrolase superfamily. Lipase family. | 0.402 |
PRMT2 | UMODL1 | ENSP00000380759 | ENSP00000386126 | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)- mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. | Uromodulin like 1. | 0.465 |
TMPRSS3 | UBASH3A | ENSP00000411013 | ENSP00000317327 | Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). | Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B- dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. | 0.545 |
TMPRSS3 | UMODL1 | ENSP00000411013 | ENSP00000386126 | Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). | Uromodulin like 1. | 0.451 |
UBASH3A | TMPRSS3 | ENSP00000317327 | ENSP00000411013 | Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B- dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. | Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). | 0.545 |
UBASH3A | UMODL1 | ENSP00000317327 | ENSP00000386126 | Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B- dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. | Uromodulin like 1. | 0.525 |
UMODL1 | AXDND1 | ENSP00000386126 | ENSP00000356590 | Uromodulin like 1. | Axonemal dynein light chain domain containing 1. | 0.492 |
UMODL1 | FAM13C | ENSP00000386126 | ENSP00000481854 | Uromodulin like 1. | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 0.471 |
UMODL1 | HSF2BP | ENSP00000386126 | ENSP00000291560 | Uromodulin like 1. | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). | 0.488 |