KLHL30 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP97	KLHL30	ENSP00000342510	ENSP00000386389	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	Kelch-like protein 30; Kelch like family member 30.	0.457
CEP97	KLHL40	ENSP00000342510	ENSP00000287777	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).	0.464
DIPK1C	KLHL30	ENSP00000344331	ENSP00000386389	Divergent protein kinase domain 1C.	Kelch-like protein 30; Kelch like family member 30.	0.468
KLHL30	CEP97	ENSP00000386389	ENSP00000342510	Kelch-like protein 30; Kelch like family member 30.	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	0.457
KLHL30	DIPK1C	ENSP00000386389	ENSP00000344331	Kelch-like protein 30; Kelch like family member 30.	Divergent protein kinase domain 1C.	0.468
KLHL30	KLHL31	ENSP00000386389	ENSP00000359942	Kelch-like protein 30; Kelch like family member 30.	Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).	0.432
KLHL30	KLHL33	ENSP00000386389	ENSP00000341549	Kelch-like protein 30; Kelch like family member 30.	Kelch-like protein 33; Kelch like family member 33.	0.431
KLHL30	KLHL40	ENSP00000386389	ENSP00000287777	Kelch-like protein 30; Kelch like family member 30.	Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).	0.450
KLHL30	METTL8	ENSP00000386389	ENSP00000480056	Kelch-like protein 30; Kelch like family member 30.	mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.	0.472
KLHL30	NANP	ENSP00000386389	ENSP00000302441	Kelch-like protein 30; Kelch like family member 30.	N-acylneuraminate-9-phosphatase; N-acetylneuraminic acid phosphatase.	0.521
KLHL30	NIF3L1	ENSP00000386389	ENSP00000498853	Kelch-like protein 30; Kelch like family member 30.	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.	0.507
KLHL30	PRPF40A	ENSP00000386389	ENSP00000386458	Kelch-like protein 30; Kelch like family member 30.	Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family.	0.442
KLHL30	WDR33	ENSP00000386389	ENSP00000325377	Kelch-like protein 30; Kelch like family member 30.	pre-mRNA 3' end processing protein WDR33; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.	0.456
KLHL31	KLHL30	ENSP00000359942	ENSP00000386389	Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).	Kelch-like protein 30; Kelch like family member 30.	0.432
KLHL31	KLHL33	ENSP00000359942	ENSP00000341549	Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).	Kelch-like protein 33; Kelch like family member 33.	0.439
KLHL31	KLHL40	ENSP00000359942	ENSP00000287777	Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).	Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).	0.619
KLHL33	KLHL30	ENSP00000341549	ENSP00000386389	Kelch-like protein 33; Kelch like family member 33.	Kelch-like protein 30; Kelch like family member 30.	0.431
KLHL33	KLHL31	ENSP00000341549	ENSP00000359942	Kelch-like protein 33; Kelch like family member 33.	Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).	0.439
KLHL40	CEP97	ENSP00000287777	ENSP00000342510	Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).	Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	0.464
KLHL40	KLHL30	ENSP00000287777	ENSP00000386389	Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).	Kelch-like protein 30; Kelch like family member 30.	0.450