CYSRT1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYSRT1	KPRP	ENSP00000386453	ENSP00000475216	Cysteine rich tail 1.	Keratinocyte proline rich protein.	0.890
CYSRT1	KRTAP1-3	ENSP00000386453	ENSP00000344420	Cysteine rich tail 1.	Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	0.918
CYSRT1	KRTAP4-4	ENSP00000386453	ENSP00000375076	Cysteine rich tail 1.	Keratin associated protein 4-4.	0.839
CYSRT1	KRTAP9-8	ENSP00000386453	ENSP00000254072	Cysteine rich tail 1.	Keratin-associated protein 9-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	0.841
CYSRT1	LCE2C	ENSP00000386453	ENSP00000357772	Cysteine rich tail 1.	Late cornified envelope protein 2C; Precursors of the cornified envelope of the stratum.	0.839
CYSRT1	LCE3A	ENSP00000386453	ENSP00000335006	Cysteine rich tail 1.	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	0.845
CYSRT1	LCE4A	ENSP00000386453	ENSP00000357766	Cysteine rich tail 1.	Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.839
CYSRT1	PLLP	ENSP00000386453	ENSP00000219207	Cysteine rich tail 1.	Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family.	0.839
CYSRT1	PRKAB2	ENSP00000386453	ENSP00000254101	Cysteine rich tail 1.	5'-AMP-activated protein kinase subunit beta-2; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]	0.839
CYSRT1	WDR25	ENSP00000386453	ENSP00000334148	Cysteine rich tail 1.	WD repeat domain 25.	0.839
KPRP	CYSRT1	ENSP00000475216	ENSP00000386453	Keratinocyte proline rich protein.	Cysteine rich tail 1.	0.890
KPRP	LCE2C	ENSP00000475216	ENSP00000357772	Keratinocyte proline rich protein.	Late cornified envelope protein 2C; Precursors of the cornified envelope of the stratum.	0.455
KPRP	LCE4A	ENSP00000475216	ENSP00000357766	Keratinocyte proline rich protein.	Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.462
KRTAP1-3	CYSRT1	ENSP00000344420	ENSP00000386453	Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	Cysteine rich tail 1.	0.918
KRTAP1-3	KRTAP4-4	ENSP00000344420	ENSP00000375076	Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	Keratin associated protein 4-4.	0.657
KRTAP1-3	KRTAP9-8	ENSP00000344420	ENSP00000254072	Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	Keratin-associated protein 9-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	0.690
KRTAP4-4	CYSRT1	ENSP00000375076	ENSP00000386453	Keratin associated protein 4-4.	Cysteine rich tail 1.	0.839
KRTAP4-4	KRTAP1-3	ENSP00000375076	ENSP00000344420	Keratin associated protein 4-4.	Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	0.657
KRTAP4-4	KRTAP9-8	ENSP00000375076	ENSP00000254072	Keratin associated protein 4-4.	Keratin-associated protein 9-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	0.898
KRTAP4-4	LCE4A	ENSP00000375076	ENSP00000357766	Keratin associated protein 4-4.	Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.543