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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRR35Proline-rich protein 35; Proline rich 35. (571 aa)    
Predicted Functional Partners:
NHLRC4
NHL-repeat-containing protein 4; NHL repeat containing 4.
 
 
    0.815
OR51A4
Olfactory receptor 51A4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.710
OR51L1
Olfactory receptor 51L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.707
OR52J3
Olfactory receptor 52J3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.694
OR51A2
Olfactory receptor 51A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.680
KBTBD12
Kelch repeat and BTB domain containing 12.
   
  
 0.676
RRP36
Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.
      
 0.647
SPATA48
Spermatogenesis-associated protein 48; Spermatogenesis associated 48.
      
 0.615
TOGARAM1
TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family.
      
 0.611
VWC2
Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).
   
  
 0.609
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.