Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ANKRD61Ankyrin repeat domain 61. (418 aa)    
Predicted Functional Partners:
FAM110D
Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family.
      
 0.665
RSPH10B
Radial spoke head 10 homolog B.
      
 0.594
PROX2
Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family.
   
  
 0.586
AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
      
 0.584
ZNF793
Zinc finger protein 793; May be involved in transcriptional regulation.
    
 
 0.559
ZNF781
Zinc finger protein 781; May be involved in transcriptional regulation.
    
 
 0.548
TRIM73
Tripartite motif containing 73; Belongs to the TRIM/RBCC family.
      
 0.547
C12orf76
Uncharacterized protein C12orf76; Chromosome 12 open reading frame 76.
      
 0.547
PGPEP1L
Pyroglutamyl-peptidase 1-like protein; Pyroglutamyl-peptidase I like.
    
 
 0.545
TMEM235
Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.
      
 0.542
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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