node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP45 | FAM174C | ENSP00000439601 | ENSP00000386557 | Minor histocompatibility antigen HA-1; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity. | Protein FAM174C; Family with sequence similarity 174 member C. | 0.499 |
ARHGAP45 | RBIS | ENSP00000439601 | ENSP00000484492 | Minor histocompatibility antigen HA-1; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity. | Ribosomal biogenesis factor; Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. | 0.409 |
ARHGAP45 | SBNO2 | ENSP00000439601 | ENSP00000354733 | Minor histocompatibility antigen HA-1; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity. | Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL- mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Pla [...] | 0.497 |
ARHGAP45 | TMEM259 | ENSP00000439601 | ENSP00000349087 | Minor histocompatibility antigen HA-1; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity. | Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. Belongs to the membralin family. | 0.406 |
ATP5F1D | FAM174C | ENSP00000215375 | ENSP00000386557 | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] | Protein FAM174C; Family with sequence similarity 174 member C. | 0.512 |
C19orf25 | CBARP | ENSP00000397394 | ENSP00000465260 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family. | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. | 0.406 |
C19orf25 | FAM174C | ENSP00000397394 | ENSP00000386557 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family. | Protein FAM174C; Family with sequence similarity 174 member C. | 0.532 |
CBARP | C19orf25 | ENSP00000465260 | ENSP00000397394 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family. | 0.406 |
CBARP | FAM174C | ENSP00000465260 | ENSP00000386557 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. | Protein FAM174C; Family with sequence similarity 174 member C. | 0.551 |
CBARP | SBNO2 | ENSP00000465260 | ENSP00000354733 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. | Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL- mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Pla [...] | 0.409 |
CCDC160 | FAM174C | ENSP00000427951 | ENSP00000386557 | Coiled-coil domain containing 160; Belongs to the CCDC160 family. | Protein FAM174C; Family with sequence similarity 174 member C. | 0.495 |
CIRBP | FAM174C | ENSP00000466025 | ENSP00000386557 | Cold-inducible RNA-binding protein; Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'- UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. | Protein FAM174C; Family with sequence similarity 174 member C. | 0.484 |
FAM174C | ARHGAP45 | ENSP00000386557 | ENSP00000439601 | Protein FAM174C; Family with sequence similarity 174 member C. | Minor histocompatibility antigen HA-1; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity. | 0.499 |
FAM174C | ATP5F1D | ENSP00000386557 | ENSP00000215375 | Protein FAM174C; Family with sequence similarity 174 member C. | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] | 0.512 |
FAM174C | C19orf25 | ENSP00000386557 | ENSP00000397394 | Protein FAM174C; Family with sequence similarity 174 member C. | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family. | 0.532 |
FAM174C | CBARP | ENSP00000386557 | ENSP00000465260 | Protein FAM174C; Family with sequence similarity 174 member C. | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. | 0.551 |
FAM174C | CCDC160 | ENSP00000386557 | ENSP00000427951 | Protein FAM174C; Family with sequence similarity 174 member C. | Coiled-coil domain containing 160; Belongs to the CCDC160 family. | 0.495 |
FAM174C | CIRBP | ENSP00000386557 | ENSP00000466025 | Protein FAM174C; Family with sequence similarity 174 member C. | Cold-inducible RNA-binding protein; Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'- UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. | 0.484 |
FAM174C | LRRCC1 | ENSP00000386557 | ENSP00000353538 | Protein FAM174C; Family with sequence similarity 174 member C. | Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. | 0.482 |
FAM174C | RBIS | ENSP00000386557 | ENSP00000484492 | Protein FAM174C; Family with sequence similarity 174 member C. | Ribosomal biogenesis factor; Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. | 0.576 |