node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APBA2 | TMEM131L | ENSP00000453293 | ENSP00000386787 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. | Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. | 0.498 |
APBA2 | TMEM229B | ENSP00000453293 | ENSP00000350050 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. | Transmembrane protein 229B. | 0.501 |
ARFIP1 | COMMD8 | ENSP00000296557 | ENSP00000370984 | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | 0.473 |
ARFIP1 | OCIAD2 | ENSP00000296557 | ENSP00000423014 | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | OCIA domain containing 2. | 0.452 |
ARFIP1 | RNF150 | ENSP00000296557 | ENSP00000425840 | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | Ring finger protein 150. | 0.463 |
ARFIP1 | SMIM14 | ENSP00000296557 | ENSP00000295958 | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | Small integral membrane protein 14. | 0.495 |
ARFIP1 | TIGD4 | ENSP00000296557 | ENSP00000355162 | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | Tigger transposable element derived 4. | 0.591 |
ARFIP1 | TMEM131L | ENSP00000296557 | ENSP00000386787 | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. | 0.491 |
C1orf21 | TMEM131L | ENSP00000235307 | ENSP00000386787 | Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21. | Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. | 0.477 |
COMMD8 | ARFIP1 | ENSP00000370984 | ENSP00000296557 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | 0.473 |
COMMD8 | OCIAD2 | ENSP00000370984 | ENSP00000423014 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | OCIA domain containing 2. | 0.479 |
COMMD8 | RNF150 | ENSP00000370984 | ENSP00000425840 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Ring finger protein 150. | 0.485 |
COMMD8 | SMIM14 | ENSP00000370984 | ENSP00000295958 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Small integral membrane protein 14. | 0.510 |
COMMD8 | TIGD4 | ENSP00000370984 | ENSP00000355162 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Tigger transposable element derived 4. | 0.539 |
COMMD8 | TMEM131L | ENSP00000370984 | ENSP00000386787 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. | 0.525 |
OCIAD2 | ARFIP1 | ENSP00000423014 | ENSP00000296557 | OCIA domain containing 2. | Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. | 0.452 |
OCIAD2 | COMMD8 | ENSP00000423014 | ENSP00000370984 | OCIA domain containing 2. | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | 0.479 |
OCIAD2 | RNF150 | ENSP00000423014 | ENSP00000425840 | OCIA domain containing 2. | Ring finger protein 150. | 0.462 |
OCIAD2 | SMIM14 | ENSP00000423014 | ENSP00000295958 | OCIA domain containing 2. | Small integral membrane protein 14. | 0.495 |
OCIAD2 | TIGD4 | ENSP00000423014 | ENSP00000355162 | OCIA domain containing 2. | Tigger transposable element derived 4. | 0.519 |