C4orf48 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C20orf141	C4orf48	ENSP00000369963	ENSP00000386807	Uncharacterized protein C20orf141; Chromosome 20 open reading frame 141.	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.437
C4orf48	C20orf141	ENSP00000386807	ENSP00000369963	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Uncharacterized protein C20orf141; Chromosome 20 open reading frame 141.	0.437
C4orf48	CAMK2N2	ENSP00000386807	ENSP00000296238	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	0.559
C4orf48	COMTD1	ENSP00000386807	ENSP00000361616	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.	0.433
C4orf48	INAFM1	ENSP00000386807	ENSP00000447679	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.495
C4orf48	NELL1	ENSP00000386807	ENSP00000298925	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.	0.950
C4orf48	NELL2	ENSP00000386807	ENSP00000416341	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).	0.874
C4orf48	SCAND1	ENSP00000386807	ENSP00000363103	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	SCAN domain-containing protein 1; May regulate transcriptional activity.	0.403
C4orf48	TGFB1	ENSP00000386807	ENSP00000221930	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.799
C4orf48	TMEM59L	ENSP00000386807	ENSP00000470879	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.605
CAMK2N2	C4orf48	ENSP00000296238	ENSP00000386807	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.559
CAMK2N2	INAFM1	ENSP00000296238	ENSP00000447679	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	Putative transmembrane protein INAFM1; InaF motif containing 1.	0.456
CAMK2N2	TMEM59L	ENSP00000296238	ENSP00000470879	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.582
COMTD1	C4orf48	ENSP00000361616	ENSP00000386807	Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.433
INAFM1	C4orf48	ENSP00000447679	ENSP00000386807	Putative transmembrane protein INAFM1; InaF motif containing 1.	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.495
INAFM1	CAMK2N2	ENSP00000447679	ENSP00000296238	Putative transmembrane protein INAFM1; InaF motif containing 1.	Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	0.456
INAFM1	TMEM59L	ENSP00000447679	ENSP00000470879	Putative transmembrane protein INAFM1; InaF motif containing 1.	Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	0.506
NELL1	C4orf48	ENSP00000298925	ENSP00000386807	Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.950
NELL1	NELL2	ENSP00000298925	ENSP00000416341	Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.	Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).	0.825
NELL2	C4orf48	ENSP00000416341	ENSP00000386807	Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).	Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.	0.874