node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHD7 | CHD8 | ENSP00000392028 | ENSP00000495240 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | 0.957 |
CHD7 | FAM124B | ENSP00000392028 | ENSP00000386895 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | 0.570 |
CHD8 | CHD7 | ENSP00000495240 | ENSP00000392028 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | 0.957 |
CHD8 | FAM124B | ENSP00000495240 | ENSP00000386895 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | 0.760 |
FAM124A | FAM124B | ENSP00000280057 | ENSP00000386895 | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family. | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | 0.433 |
FAM124A | FAM167B | ENSP00000280057 | ENSP00000362684 | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family. | Protein FAM167B; Family with sequence similarity 167 member B; Belongs to the FAM167 (SEC) family. | 0.567 |
FAM124B | CHD7 | ENSP00000386895 | ENSP00000392028 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. | 0.570 |
FAM124B | CHD8 | ENSP00000386895 | ENSP00000495240 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | 0.760 |
FAM124B | FAM124A | ENSP00000386895 | ENSP00000280057 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family. | 0.433 |
FAM124B | FAM167B | ENSP00000386895 | ENSP00000362684 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Protein FAM167B; Family with sequence similarity 167 member B; Belongs to the FAM167 (SEC) family. | 0.437 |
FAM124B | FAM174B | ENSP00000386895 | ENSP00000329040 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Membrane protein FAM174B; Essential for Golgi structural integrity. | 0.521 |
FAM124B | MANEAL | ENSP00000386895 | ENSP00000362136 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family. | 0.448 |
FAM124B | MDFI | ENSP00000386895 | ENSP00000230321 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | MyoD family inhibitor; Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA- binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the l [...] | 0.504 |
FAM124B | OR2A2 | ENSP00000386895 | ENSP00000386209 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Olfactory receptor 2A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.478 |
FAM124B | SPATA13 | ENSP00000386895 | ENSP00000398560 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Spermatogenesis-associated protein 13; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. | 0.444 |
FAM124B | ZNF254 | ENSP00000386895 | ENSP00000349494 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | Zinc finger protein 254; May be involved in transcriptional regulation. | 0.420 |
FAM167B | FAM124A | ENSP00000362684 | ENSP00000280057 | Protein FAM167B; Family with sequence similarity 167 member B; Belongs to the FAM167 (SEC) family. | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family. | 0.567 |
FAM167B | FAM124B | ENSP00000362684 | ENSP00000386895 | Protein FAM167B; Family with sequence similarity 167 member B; Belongs to the FAM167 (SEC) family. | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | 0.437 |
FAM174B | FAM124B | ENSP00000329040 | ENSP00000386895 | Membrane protein FAM174B; Essential for Golgi structural integrity. | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | 0.521 |
MANEAL | FAM124B | ENSP00000362136 | ENSP00000386895 | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family. | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family. | 0.448 |