| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| B9D1 | CC2D2B | ENSP00000261499 | ENSP00000386988 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | 0.547 |
| B9D1 | NPHP4 | ENSP00000261499 | ENSP00000367398 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subce [...] | 0.868 |
| B9D1 | RPGRIP1L | ENSP00000261499 | ENSP00000369257 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | Protein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left- right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled protein [...] | 0.865 |
| CC2D2B | B9D1 | ENSP00000386988 | ENSP00000261499 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | 0.547 |
| CC2D2B | CCDC135 | ENSP00000386988 | ENSP00000353942 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.505 |
| CC2D2B | CITED1 | ENSP00000386988 | ENSP00000401764 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Cbp/p300-interacting transactivator 1; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional c [...] | 0.452 |
| CC2D2B | LRRC2 | ENSP00000386988 | ENSP00000379241 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | 0.465 |
| CC2D2B | NPHP4 | ENSP00000386988 | ENSP00000367398 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subce [...] | 0.492 |
| CC2D2B | PIGM | ENSP00000386988 | ENSP00000357069 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly; Belongs to the PIGM family | 0.539 |
| CC2D2B | RPGRIP1L | ENSP00000386988 | ENSP00000369257 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Protein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left- right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled protein [...] | 0.514 |
| CC2D2B | SAA2-SAA4 | ENSP00000386988 | ENSP00000485552 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Serum amyloid a protein; SAA2-SAA4 readthrough | 0.561 |
| CC2D2B | SERGEF | ENSP00000386988 | ENSP00000265965 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Secretion-regulating guanine nucleotide exchange factor; Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process | 0.547 |
| CC2D2B | STK32A | ENSP00000386988 | ENSP00000381535 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | Serine/threonine-protein kinase 32a; Serine/threonine kinase 32A | 0.517 |
| CCDC135 | CC2D2B | ENSP00000353942 | ENSP00000386988 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | 0.505 |
| CCDC135 | NPHP4 | ENSP00000353942 | ENSP00000367398 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subce [...] | 0.441 |
| CITED1 | CC2D2B | ENSP00000401764 | ENSP00000386988 | Cbp/p300-interacting transactivator 1; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional c [...] | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | 0.452 |
| LRRC2 | CC2D2B | ENSP00000379241 | ENSP00000386988 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | 0.465 |
| NPHP4 | B9D1 | ENSP00000367398 | ENSP00000261499 | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subce [...] | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the B9D family | 0.868 |
| NPHP4 | CC2D2B | ENSP00000367398 | ENSP00000386988 | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subce [...] | Protein CC2D2B; Coiled-coil and C2 domain containing 2B | 0.492 |
| NPHP4 | CCDC135 | ENSP00000367398 | ENSP00000353942 | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subce [...] | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.441 |
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