WDSUB1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	TANC1	ENSP00000220592	ENSP00000263635	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein TANC1; May be a scaffold component in the postsynaptic density.	0.485
AGO2	WDSUB1	ENSP00000220592	ENSP00000387078	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	WD repeat, sterile alpha motif and U-box domain containing 1.	0.457
ATG16L2	WDR86	ENSP00000326340	ENSP00000419162	Autophagy-related protein 16-2; May play a role in autophagy.	WD repeat domain 86.	0.455
ATG16L2	WDSUB1	ENSP00000326340	ENSP00000387078	Autophagy-related protein 16-2; May play a role in autophagy.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.438
BAZ2B	TANC1	ENSP00000376534	ENSP00000263635	Bromodomain adjacent to zinc finger domain protein 2B; May play a role in transcriptional regulation interacting with ISWI; Belongs to the WAL family.	Protein TANC1; May be a scaffold component in the postsynaptic density.	0.434
BAZ2B	WDSUB1	ENSP00000376534	ENSP00000387078	Bromodomain adjacent to zinc finger domain protein 2B; May play a role in transcriptional regulation interacting with ISWI; Belongs to the WAL family.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.779
BTBD2	WDSUB1	ENSP00000255608	ENSP00000387078	BTB/POZ domain-containing protein 2; BTB domain containing 2.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.460
FBXO25	WDSUB1	ENSP00000372274	ENSP00000387078	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	WD repeat, sterile alpha motif and U-box domain containing 1.	0.476
TANC1	AGO2	ENSP00000263635	ENSP00000220592	Protein TANC1; May be a scaffold component in the postsynaptic density.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.485
TANC1	BAZ2B	ENSP00000263635	ENSP00000376534	Protein TANC1; May be a scaffold component in the postsynaptic density.	Bromodomain adjacent to zinc finger domain protein 2B; May play a role in transcriptional regulation interacting with ISWI; Belongs to the WAL family.	0.434
TANC1	WDSUB1	ENSP00000263635	ENSP00000387078	Protein TANC1; May be a scaffold component in the postsynaptic density.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.430
UBE4A	WDSUB1	ENSP00000387362	ENSP00000387078	Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.460
UBOX5	WDSUB1	ENSP00000217173	ENSP00000387078	RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.673
WDR31	WDR86	ENSP00000363308	ENSP00000419162	WD repeat domain 31.	WD repeat domain 86.	0.501
WDR31	WDSUB1	ENSP00000363308	ENSP00000387078	WD repeat domain 31.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.544
WDR86	ATG16L2	ENSP00000419162	ENSP00000326340	WD repeat domain 86.	Autophagy-related protein 16-2; May play a role in autophagy.	0.455
WDR86	WDR31	ENSP00000419162	ENSP00000363308	WD repeat domain 86.	WD repeat domain 31.	0.501
WDR86	WDSUB1	ENSP00000419162	ENSP00000387078	WD repeat domain 86.	WD repeat, sterile alpha motif and U-box domain containing 1.	0.476
WDSUB1	AGO2	ENSP00000387078	ENSP00000220592	WD repeat, sterile alpha motif and U-box domain containing 1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.457
WDSUB1	ATG16L2	ENSP00000387078	ENSP00000326340	WD repeat, sterile alpha motif and U-box domain containing 1.	Autophagy-related protein 16-2; May play a role in autophagy.	0.438