node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALB1 | NECAB1 | ENSP00000265431 | ENSP00000387380 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | N-terminal EF-hand calcium binding protein 1. | 0.457 |
CALB1 | NECAB2 | ENSP00000265431 | ENSP00000307449 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. | 0.529 |
CALB2 | NECAB1 | ENSP00000307508 | ENSP00000387380 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; Belongs to the calbindin family. | N-terminal EF-hand calcium binding protein 1. | 0.445 |
EFCAB1 | NECAB1 | ENSP00000262103 | ENSP00000387380 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | N-terminal EF-hand calcium binding protein 1. | 0.413 |
EFCAB1 | WDR90 | ENSP00000262103 | ENSP00000293879 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | WD repeat-containing protein 90; Required for efficient primary cilium formation. | 0.430 |
H3BUI4_HUMAN | NECAB1 | ENSP00000457654 | ENSP00000387380 | Uncharacterized protein. | N-terminal EF-hand calcium binding protein 1. | 0.434 |
KLHL32 | NECAB1 | ENSP00000358265 | ENSP00000387380 | Kelch-like protein 32; Kelch like family member 32. | N-terminal EF-hand calcium binding protein 1. | 0.410 |
KRTAP10-4 | NECAB1 | ENSP00000383225 | ENSP00000387380 | Keratin-associated protein 10-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | N-terminal EF-hand calcium binding protein 1. | 0.416 |
KRTAP10-4 | WDR90 | ENSP00000383225 | ENSP00000293879 | Keratin-associated protein 10-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | WD repeat-containing protein 90; Required for efficient primary cilium formation. | 0.445 |
NECAB1 | CALB1 | ENSP00000387380 | ENSP00000265431 | N-terminal EF-hand calcium binding protein 1. | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | 0.457 |
NECAB1 | CALB2 | ENSP00000387380 | ENSP00000307508 | N-terminal EF-hand calcium binding protein 1. | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; Belongs to the calbindin family. | 0.445 |
NECAB1 | EFCAB1 | ENSP00000387380 | ENSP00000262103 | N-terminal EF-hand calcium binding protein 1. | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1. | 0.413 |
NECAB1 | H3BUI4_HUMAN | ENSP00000387380 | ENSP00000457654 | N-terminal EF-hand calcium binding protein 1. | Uncharacterized protein. | 0.434 |
NECAB1 | KLHL32 | ENSP00000387380 | ENSP00000358265 | N-terminal EF-hand calcium binding protein 1. | Kelch-like protein 32; Kelch like family member 32. | 0.410 |
NECAB1 | KRTAP10-4 | ENSP00000387380 | ENSP00000383225 | N-terminal EF-hand calcium binding protein 1. | Keratin-associated protein 10-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | 0.416 |
NECAB1 | NECAB2 | ENSP00000387380 | ENSP00000307449 | N-terminal EF-hand calcium binding protein 1. | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. | 0.792 |
NECAB1 | NECAB3 | ENSP00000387380 | ENSP00000246190 | N-terminal EF-hand calcium binding protein 1. | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3. | 0.798 |
NECAB1 | SYT1 | ENSP00000387380 | ENSP00000261205 | N-terminal EF-hand calcium binding protein 1. | Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] | 0.573 |
NECAB1 | WDR90 | ENSP00000387380 | ENSP00000293879 | N-terminal EF-hand calcium binding protein 1. | WD repeat-containing protein 90; Required for efficient primary cilium formation. | 0.566 |
NECAB2 | CALB1 | ENSP00000307449 | ENSP00000265431 | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | 0.529 |