ZBTB10 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	ZBTB10	ENSP00000220592	ENSP00000387462	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.827
FBXL17	ZBTB10	ENSP00000437464	ENSP00000387462	F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB di [...]	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.923
FBXL17	ZBTB46	ENSP00000437464	ENSP00000378536	F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB di [...]	Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1.	0.579
HIRA	ZBTB10	ENSP00000263208	ENSP00000387462	Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.618
HPS1	ZBTB10	ENSP00000326649	ENSP00000387462	Hermansky-Pudlak syndrome 1 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.682
KLHL29	ZBTB10	ENSP00000420659	ENSP00000387462	Kelch-like protein 29; Kelch like family member 29.	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.638
MOB3C	ZBTB10	ENSP00000271139	ENSP00000387462	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.600
RFPL4B	ZBTB10	ENSP00000423391	ENSP00000387462	Ret finger protein like 4B.	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.591
ZBTB10	AGO2	ENSP00000387462	ENSP00000220592	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.827
ZBTB10	FBXL17	ENSP00000387462	ENSP00000437464	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB di [...]	0.923
ZBTB10	HIRA	ENSP00000387462	ENSP00000263208	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.	0.618
ZBTB10	HPS1	ENSP00000387462	ENSP00000326649	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Hermansky-Pudlak syndrome 1 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38.	0.682
ZBTB10	KLHL29	ENSP00000387462	ENSP00000420659	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Kelch-like protein 29; Kelch like family member 29.	0.638
ZBTB10	MOB3C	ENSP00000387462	ENSP00000271139	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	0.600
ZBTB10	RFPL4B	ENSP00000387462	ENSP00000423391	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Ret finger protein like 4B.	0.591
ZBTB10	ZBTB46	ENSP00000387462	ENSP00000378536	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1.	0.596
ZBTB10	ZNF460	ENSP00000387462	ENSP00000353491	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Zinc finger protein 460; May be involved in transcriptional regulation.	0.633
ZBTB10	ZNF576	ENSP00000387462	ENSP00000337852	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	Zinc finger protein 576; May be involved in transcriptional regulation.	0.629
ZBTB46	FBXL17	ENSP00000378536	ENSP00000437464	Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1.	F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB di [...]	0.579
ZBTB46	ZBTB10	ENSP00000378536	ENSP00000387462	Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1.	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.596