node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP1 | TMEM251 | ENSP00000272067 | ENSP00000388431 | Low molecular weight phosphotyrosine protein phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. | Transmembrane protein 251; Belongs to the TMEM251 family. | 0.475 |
KRTAP4-8 | PWWP2B | ENSP00000328444 | ENSP00000306324 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | PWWP domain containing 2B. | 0.444 |
KRTAP4-8 | TMEM251 | ENSP00000328444 | ENSP00000388431 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | Transmembrane protein 251; Belongs to the TMEM251 family. | 0.492 |
PWWP2B | KRTAP4-8 | ENSP00000306324 | ENSP00000328444 | PWWP domain containing 2B. | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | 0.444 |
PWWP2B | TAF5L | ENSP00000306324 | ENSP00000258281 | PWWP domain containing 2B. | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...] | 0.497 |
PWWP2B | TMEM251 | ENSP00000306324 | ENSP00000388431 | PWWP domain containing 2B. | Transmembrane protein 251; Belongs to the TMEM251 family. | 0.606 |
PWWP2B | ZMYM2 | ENSP00000306324 | ENSP00000479904 | PWWP domain containing 2B. | Zinc finger MYM-type protein 2; May function as a transcription factor. | 0.448 |
TAF5L | PWWP2B | ENSP00000258281 | ENSP00000306324 | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...] | PWWP domain containing 2B. | 0.497 |
TAF5L | TMEM251 | ENSP00000258281 | ENSP00000388431 | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...] | Transmembrane protein 251; Belongs to the TMEM251 family. | 0.520 |
TAF5L | ZMYM2 | ENSP00000258281 | ENSP00000479904 | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...] | Zinc finger MYM-type protein 2; May function as a transcription factor. | 0.448 |
TMEM251 | ACP1 | ENSP00000388431 | ENSP00000272067 | Transmembrane protein 251; Belongs to the TMEM251 family. | Low molecular weight phosphotyrosine protein phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. | 0.475 |
TMEM251 | KRTAP4-8 | ENSP00000388431 | ENSP00000328444 | Transmembrane protein 251; Belongs to the TMEM251 family. | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 4 family. | 0.492 |
TMEM251 | PWWP2B | ENSP00000388431 | ENSP00000306324 | Transmembrane protein 251; Belongs to the TMEM251 family. | PWWP domain containing 2B. | 0.606 |
TMEM251 | TAF5L | ENSP00000388431 | ENSP00000258281 | Transmembrane protein 251; Belongs to the TMEM251 family. | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...] | 0.520 |
TMEM251 | TMEM41B | ENSP00000388431 | ENSP00000433126 | Transmembrane protein 251; Belongs to the TMEM251 family. | Transmembrane protein 41B; Required for normal motor neuron development (By similarity). Required for autophagosome formation. Belongs to the TMEM41 family. | 0.478 |
TMEM251 | ZMYM2 | ENSP00000388431 | ENSP00000479904 | Transmembrane protein 251; Belongs to the TMEM251 family. | Zinc finger MYM-type protein 2; May function as a transcription factor. | 0.471 |
TMEM41B | TMEM251 | ENSP00000433126 | ENSP00000388431 | Transmembrane protein 41B; Required for normal motor neuron development (By similarity). Required for autophagosome formation. Belongs to the TMEM41 family. | Transmembrane protein 251; Belongs to the TMEM251 family. | 0.478 |
ZMYM2 | PWWP2B | ENSP00000479904 | ENSP00000306324 | Zinc finger MYM-type protein 2; May function as a transcription factor. | PWWP domain containing 2B. | 0.448 |
ZMYM2 | TAF5L | ENSP00000479904 | ENSP00000258281 | Zinc finger MYM-type protein 2; May function as a transcription factor. | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By [...] | 0.448 |
ZMYM2 | TMEM251 | ENSP00000479904 | ENSP00000388431 | Zinc finger MYM-type protein 2; May function as a transcription factor. | Transmembrane protein 251; Belongs to the TMEM251 family. | 0.471 |