node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A1BG | CRISP3 | ENSP00000263100 | ENSP00000389026 | Alpha-1B-glycoprotein; alpha-1-B glycoprotein. | Cysteine rich secretory protein 3; Belongs to the CRISP family. | 0.941 |
A1BG | MSMB | ENSP00000263100 | ENSP00000463092 | Alpha-1B-glycoprotein; alpha-1-B glycoprotein. | Beta-microseminoprotein; Microseminoprotein beta. | 0.407 |
CRISP2 | CRISP3 | ENSP00000484609 | ENSP00000389026 | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | Cysteine rich secretory protein 3; Belongs to the CRISP family. | 0.666 |
CRISP2 | GART | ENSP00000484609 | ENSP00000371253 | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | 0.831 |
CRISP2 | IL4I1 | ENSP00000484609 | ENSP00000472474 | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity). | 0.657 |
CRISP2 | MSMB | ENSP00000484609 | ENSP00000463092 | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | Beta-microseminoprotein; Microseminoprotein beta. | 0.417 |
CRISP2 | PLB1 | ENSP00000484609 | ENSP00000330442 | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). | 0.655 |
CRISP3 | A1BG | ENSP00000389026 | ENSP00000263100 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Alpha-1B-glycoprotein; alpha-1-B glycoprotein. | 0.941 |
CRISP3 | CRISP2 | ENSP00000389026 | ENSP00000484609 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | 0.666 |
CRISP3 | GART | ENSP00000389026 | ENSP00000371253 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | 0.831 |
CRISP3 | IL4I1 | ENSP00000389026 | ENSP00000472474 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity). | 0.625 |
CRISP3 | LCN2 | ENSP00000389026 | ENSP00000362108 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Neutrophil gelatinase-associated lipocalin; Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of [...] | 0.627 |
CRISP3 | MMP8 | ENSP00000389026 | ENSP00000236826 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens; Belongs to the peptidase M10A family. | 0.672 |
CRISP3 | MSMB | ENSP00000389026 | ENSP00000463092 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Beta-microseminoprotein; Microseminoprotein beta. | 0.726 |
CRISP3 | MTDH | ENSP00000389026 | ENSP00000338235 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Protein LYRIC; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. | 0.761 |
CRISP3 | OLFM4 | ENSP00000389026 | ENSP00000219022 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Olfactomedin-4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. | 0.626 |
CRISP3 | PLB1 | ENSP00000389026 | ENSP00000330442 | Cysteine rich secretory protein 3; Belongs to the CRISP family. | Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). | 0.619 |
GART | CRISP2 | ENSP00000371253 | ENSP00000484609 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | 0.831 |
GART | CRISP3 | ENSP00000371253 | ENSP00000389026 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family. | Cysteine rich secretory protein 3; Belongs to the CRISP family. | 0.831 |
IL4I1 | CRISP2 | ENSP00000472474 | ENSP00000484609 | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity). | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. | 0.657 |