STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRRC23Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23. (343 aa)    
Predicted Functional Partners:
TSNAXIP1
Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis.
   
 
 0.672
CCDC113
Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.
   
  
 0.651
CFAP52
Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family.
   
 
 0.648
LRRC34
Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.
   
  
 0.619
CFAP161
Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly.
   
  
 0.588
RSPH14
Radial spoke head 14 homolog; Belongs to the flagellar radial spoke RSP14 family.
   
 
 0.570
CCDC146
Coiled-coil domain containing 146.
   
 
 0.538
CFAP45
Cilia and flagella associated protein 45.
   
 
 0.535
CFAP74
Cilia- and flagella-associated protein 74; As part of the central apparatus of the cilium axoneme may play a role in cilium movement.
   
 
 0.530
DLEC1
Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation.
   
 
 0.525
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.