node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD60 | C12orf42 | ENSP00000396747 | ENSP00000367353 | Ankyrin repeat domain 60. | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42. | 0.482 |
ANKRD60 | CCDC74B | ENSP00000396747 | ENSP00000308873 | Ankyrin repeat domain 60. | Coiled-coil domain containing 74B. | 0.528 |
ANKRD60 | LRRC63 | ENSP00000396747 | ENSP00000469337 | Ankyrin repeat domain 60. | Leucine-rich repeat-containing protein 63; Leucine rich repeat containing 63. | 0.632 |
ANKRD60 | SPATA31A1 | ENSP00000396747 | ENSP00000498856 | Ankyrin repeat domain 60. | Spermatogenesis-associated protein 31A1; May play a role in spermatogenesis; Belongs to the SPATA31 family. | 0.571 |
ANKRD60 | TTLL8 | ENSP00000396747 | ENSP00000392252 | Ankyrin repeat domain 60. | Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity). | 0.503 |
ATAT1 | TTLL8 | ENSP00000327832 | ENSP00000392252 | Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] | Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity). | 0.442 |
C12orf42 | ANKRD60 | ENSP00000367353 | ENSP00000396747 | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42. | Ankyrin repeat domain 60. | 0.482 |
C12orf42 | CCDC74B | ENSP00000367353 | ENSP00000308873 | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42. | Coiled-coil domain containing 74B. | 0.523 |
C12orf42 | LRRC63 | ENSP00000367353 | ENSP00000469337 | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42. | Leucine-rich repeat-containing protein 63; Leucine rich repeat containing 63. | 0.568 |
C12orf42 | SPATA31A1 | ENSP00000367353 | ENSP00000498856 | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42. | Spermatogenesis-associated protein 31A1; May play a role in spermatogenesis; Belongs to the SPATA31 family. | 0.506 |
C12orf42 | TTLL8 | ENSP00000367353 | ENSP00000392252 | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42. | Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity). | 0.454 |
CCDC74B | ANKRD60 | ENSP00000308873 | ENSP00000396747 | Coiled-coil domain containing 74B. | Ankyrin repeat domain 60. | 0.528 |
CCDC74B | C12orf42 | ENSP00000308873 | ENSP00000367353 | Coiled-coil domain containing 74B. | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42. | 0.523 |
CCDC74B | LRRC63 | ENSP00000308873 | ENSP00000469337 | Coiled-coil domain containing 74B. | Leucine-rich repeat-containing protein 63; Leucine rich repeat containing 63. | 0.667 |
CCDC74B | SPATA31A1 | ENSP00000308873 | ENSP00000498856 | Coiled-coil domain containing 74B. | Spermatogenesis-associated protein 31A1; May play a role in spermatogenesis; Belongs to the SPATA31 family. | 0.541 |
CCDC74B | TTLL8 | ENSP00000308873 | ENSP00000392252 | Coiled-coil domain containing 74B. | Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity). | 0.470 |
DCP1A | DCP1B | ENSP00000476386 | ENSP00000280665 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family. | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | 0.991 |
DCP1A | DCP2 | ENSP00000476386 | ENSP00000373715 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family. | m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Plays a role in replication- dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second tran [...] | 0.999 |
DCP1A | TTLL8 | ENSP00000476386 | ENSP00000392252 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family. | Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity). | 0.450 |
DCP1B | DCP1A | ENSP00000280665 | ENSP00000476386 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family. | 0.991 |