PRRT3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM229B	GASK1A	ENSP00000357645	ENSP00000407301	Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family.	Golgi associated kinase 1A; Belongs to the GASK family.	0.535
FAM229B	PRRT3	ENSP00000357645	ENSP00000392511	Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family.	Proline rich transmembrane protein 3.	0.517
GASK1A	FAM229B	ENSP00000407301	ENSP00000357645	Golgi associated kinase 1A; Belongs to the GASK family.	Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family.	0.535
GASK1A	PRRT3	ENSP00000407301	ENSP00000392511	Golgi associated kinase 1A; Belongs to the GASK family.	Proline rich transmembrane protein 3.	0.476
PRRT2	PRRT3	ENSP00000456226	ENSP00000392511	Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation.	Proline rich transmembrane protein 3.	0.538
PRRT3	FAM229B	ENSP00000392511	ENSP00000357645	Proline rich transmembrane protein 3.	Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family.	0.517
PRRT3	GASK1A	ENSP00000392511	ENSP00000407301	Proline rich transmembrane protein 3.	Golgi associated kinase 1A; Belongs to the GASK family.	0.476
PRRT3	PRRT2	ENSP00000392511	ENSP00000456226	Proline rich transmembrane protein 3.	Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation.	0.538
PRRT3	SMKR1	ENSP00000392511	ENSP00000454370	Proline rich transmembrane protein 3.	Small lysine rich protein 1.	0.454
PRRT3	SPRTN	ENSP00000392511	ENSP00000295050	Proline rich transmembrane protein 3.	SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...]	0.433
PRRT3	TATDN2	ENSP00000392511	ENSP00000287652	Proline rich transmembrane protein 3.	Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease.	0.452
PRRT3	VIRMA	ENSP00000392511	ENSP00000297591	Proline rich transmembrane protein 3.	Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...]	0.457
PRRT3	VSTM2L	ENSP00000392511	ENSP00000362560	Proline rich transmembrane protein 3.	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.	0.534
PRRT3	ZC3H8	ENSP00000392511	ENSP00000386488	Proline rich transmembrane protein 3.	Zinc finger CCCH domain-containing protein 8; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.	0.407
PRRT3	ZZEF1	ENSP00000392511	ENSP00000371051	Proline rich transmembrane protein 3.	Zinc finger ZZ-type and EF-hand domain containing 1.	0.463
SMKR1	PRRT3	ENSP00000454370	ENSP00000392511	Small lysine rich protein 1.	Proline rich transmembrane protein 3.	0.454
SPRTN	PRRT3	ENSP00000295050	ENSP00000392511	SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...]	Proline rich transmembrane protein 3.	0.433
TATDN2	PRRT3	ENSP00000287652	ENSP00000392511	Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease.	Proline rich transmembrane protein 3.	0.452
TATDN2	VIRMA	ENSP00000287652	ENSP00000297591	Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease.	Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...]	0.457
VIRMA	PRRT3	ENSP00000297591	ENSP00000392511	Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...]	Proline rich transmembrane protein 3.	0.457