node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AS3MT | CNNM2 | ENSP00000358896 | ENSP00000358894 | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | 0.818 |
AS3MT | NT5C2 | ENSP00000358896 | ENSP00000339479 | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | 0.618 |
AS3MT | POM121L2 | ENSP00000358896 | ENSP00000392726 | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.463 |
CNNM2 | AS3MT | ENSP00000358894 | ENSP00000358896 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. | 0.818 |
CNNM2 | NT5C2 | ENSP00000358894 | ENSP00000339479 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | 0.790 |
CNNM2 | POM121L2 | ENSP00000358894 | ENSP00000392726 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.488 |
HMGN4 | POM121L2 | ENSP00000366798 | ENSP00000392726 | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.472 |
HMGN4 | ZNF184 | ENSP00000366798 | ENSP00000211936 | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family. | Zinc finger protein 184; May be involved in transcriptional regulation. | 0.416 |
NT5C2 | AS3MT | ENSP00000339479 | ENSP00000358896 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. | 0.618 |
NT5C2 | CNNM2 | ENSP00000339479 | ENSP00000358894 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | 0.790 |
NT5C2 | POM121L2 | ENSP00000339479 | ENSP00000392726 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.617 |
OR14J1 | POM121L2 | ENSP00000492893 | ENSP00000392726 | Olfactory receptor 14J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.501 |
POM121 | POM121C | ENSP00000378687 | ENSP00000481575 | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Belongs to the POM121 family. | 0.931 |
POM121 | POM121L2 | ENSP00000378687 | ENSP00000392726 | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.904 |
POM121C | POM121 | ENSP00000481575 | ENSP00000378687 | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Belongs to the POM121 family. | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). | 0.931 |
POM121C | POM121L2 | ENSP00000481575 | ENSP00000392726 | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Belongs to the POM121 family. | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | 0.900 |
POM121L2 | AS3MT | ENSP00000392726 | ENSP00000358896 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. | 0.463 |
POM121L2 | CNNM2 | ENSP00000392726 | ENSP00000358894 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | 0.488 |
POM121L2 | HMGN4 | ENSP00000392726 | ENSP00000366798 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family. | 0.472 |
POM121L2 | NT5C2 | ENSP00000392726 | ENSP00000339479 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | 0.617 |