node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKHD1 | ZNF655 | ENSP00000354085 | ENSP00000393876 | Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Belongs to the mask family. | Zinc finger protein 655; May be involved in transcriptional regulation. | 0.485 |
C4BPB | ZNF655 | ENSP00000243611 | ENSP00000393876 | C4b-binding protein beta chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. | Zinc finger protein 655; May be involved in transcriptional regulation. | 0.482 |
CBY2 | ZNF655 | ENSP00000309189 | ENSP00000393876 | Chibby family member 2. | Zinc finger protein 655; May be involved in transcriptional regulation. | 0.412 |
INTS13 | INTS14 | ENSP00000261191 | ENSP00000498715 | Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. | Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing; Belongs to the INTS14 family. | 0.999 |
INTS13 | ZNF655 | ENSP00000261191 | ENSP00000393876 | Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. | Zinc finger protein 655; May be involved in transcriptional regulation. | 0.591 |
INTS14 | INTS13 | ENSP00000498715 | ENSP00000261191 | Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing; Belongs to the INTS14 family. | Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. | 0.999 |
INTS14 | ZNF655 | ENSP00000498715 | ENSP00000393876 | Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing; Belongs to the INTS14 family. | Zinc finger protein 655; May be involved in transcriptional regulation. | 0.471 |
TRIM28 | ZNF655 | ENSP00000253024 | ENSP00000393876 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 655; May be involved in transcriptional regulation. | 0.573 |
VAV1 | ZNF655 | ENSP00000472929 | ENSP00000393876 | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | Zinc finger protein 655; May be involved in transcriptional regulation. | 0.602 |
ZNF655 | ANKHD1 | ENSP00000393876 | ENSP00000354085 | Zinc finger protein 655; May be involved in transcriptional regulation. | Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Belongs to the mask family. | 0.485 |
ZNF655 | C4BPB | ENSP00000393876 | ENSP00000243611 | Zinc finger protein 655; May be involved in transcriptional regulation. | C4b-binding protein beta chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. | 0.482 |
ZNF655 | CBY2 | ENSP00000393876 | ENSP00000309189 | Zinc finger protein 655; May be involved in transcriptional regulation. | Chibby family member 2. | 0.412 |
ZNF655 | INTS13 | ENSP00000393876 | ENSP00000261191 | Zinc finger protein 655; May be involved in transcriptional regulation. | Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. | 0.591 |
ZNF655 | INTS14 | ENSP00000393876 | ENSP00000498715 | Zinc finger protein 655; May be involved in transcriptional regulation. | Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing; Belongs to the INTS14 family. | 0.471 |
ZNF655 | TRIM28 | ENSP00000393876 | ENSP00000253024 | Zinc finger protein 655; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.573 |
ZNF655 | VAV1 | ENSP00000393876 | ENSP00000472929 | Zinc finger protein 655; May be involved in transcriptional regulation. | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.602 |