Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TTC39ATetratricopeptide repeat domain 39A. (613 aa)    
Predicted Functional Partners:
P2RY12
P2Y purinoceptor 12; Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
    
 
 0.806
ZNF19
Zinc finger protein 19; May be involved in transcriptional regulation.
   
  
 0.547
NIPAL2
NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family.
   
  
 0.501
UBE2Q2L
Putative ubiquitin-conjugating enzyme E2Q2-like protein; Ubiquitin conjugating enzyme E2 Q2 like; Belongs to the ubiquitin-conjugating enzyme family.
      
 0.491
CCDC92
Coiled-coil domain containing 92.
      
 0.479
CMTR1
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
      
 0.469
KTI12
KTI12 chromatin associated homolog.
      
 0.445
OSBPL9
Oxysterol binding protein like 9; Belongs to the OSBP family.
      
 0.437
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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