TMEM182 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSPB7	TMEM182	ENSP00000364870	ENSP00000394178	Heat shock protein family B member 7; Belongs to the small heat shock protein (HSP20) family.	Transmembrane protein 182.	0.455
MCTP2	TMEM182	ENSP00000350377	ENSP00000394178	Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family.	Transmembrane protein 182.	0.454
MFSD9	TMEM182	ENSP00000258436	ENSP00000394178	Major facilitator superfamily domain containing 9.	Transmembrane protein 182.	0.682
MLIP	TMEM182	ENSP00000426290	ENSP00000394178	Muscular LMNA interacting protein.	Transmembrane protein 182.	0.552
MS4A3	TMEM182	ENSP00000278865	ENSP00000394178	Membrane-spanning 4-domains subfamily A member 3; Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP); Belongs to the MS4A family.	Transmembrane protein 182.	0.524
PLCH2	TAFA1	ENSP00000367747	ENSP00000418575	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).	Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family.	0.425
PLCH2	TMEM182	ENSP00000367747	ENSP00000394178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).	Transmembrane protein 182.	0.467
RIT1	TMEM182	ENSP00000357305	ENSP00000394178	GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation; Belongs to the small GTPase superfamily. Ras family.	Transmembrane protein 182.	0.841
TAFA1	PLCH2	ENSP00000418575	ENSP00000367747	Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).	0.425
TAFA1	TMEM182	ENSP00000418575	ENSP00000394178	Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family.	Transmembrane protein 182.	0.487
TM6SF1	TMEM182	ENSP00000317000	ENSP00000394178	Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family.	Transmembrane protein 182.	0.472
TMEM140	TMEM182	ENSP00000275767	ENSP00000394178	Transmembrane protein 140.	Transmembrane protein 182.	0.517
TMEM182	HSPB7	ENSP00000394178	ENSP00000364870	Transmembrane protein 182.	Heat shock protein family B member 7; Belongs to the small heat shock protein (HSP20) family.	0.455
TMEM182	MCTP2	ENSP00000394178	ENSP00000350377	Transmembrane protein 182.	Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family.	0.454
TMEM182	MFSD9	ENSP00000394178	ENSP00000258436	Transmembrane protein 182.	Major facilitator superfamily domain containing 9.	0.682
TMEM182	MLIP	ENSP00000394178	ENSP00000426290	Transmembrane protein 182.	Muscular LMNA interacting protein.	0.552
TMEM182	MS4A3	ENSP00000394178	ENSP00000278865	Transmembrane protein 182.	Membrane-spanning 4-domains subfamily A member 3; Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP); Belongs to the MS4A family.	0.524
TMEM182	PLCH2	ENSP00000394178	ENSP00000367747	Transmembrane protein 182.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).	0.467
TMEM182	RIT1	ENSP00000394178	ENSP00000357305	Transmembrane protein 182.	GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation; Belongs to the small GTPase superfamily. Ras family.	0.841
TMEM182	TAFA1	ENSP00000394178	ENSP00000418575	Transmembrane protein 182.	Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family.	0.487