| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL16 | CDKN2AIPNL | ENSP00000380635 | ENSP00000394183 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16. | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 0.515 |
| BRD4 | CDKN2AIPNL | ENSP00000263377 | ENSP00000394183 | Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal- inducible genes by associating with the P-TEFb complex and re [...] | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 0.457 |
| BRD4 | XRN2 | ENSP00000263377 | ENSP00000366396 | Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal- inducible genes by associating with the P-TEFb complex and re [...] | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | 0.847 |
| CDKN2AIPNL | ARL16 | ENSP00000394183 | ENSP00000380635 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16. | 0.515 |
| CDKN2AIPNL | BRD4 | ENSP00000394183 | ENSP00000263377 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal- inducible genes by associating with the P-TEFb complex and re [...] | 0.457 |
| CDKN2AIPNL | CUL7 | ENSP00000394183 | ENSP00000438788 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.457 |
| CDKN2AIPNL | EID2B | ENSP00000394183 | ENSP00000317564 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | EP300-interacting inhibitor of differentiation 2B; Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation. | 0.510 |
| CDKN2AIPNL | IQCF6 | ENSP00000394183 | ENSP00000381760 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | IQ motif containing F6. | 0.436 |
| CDKN2AIPNL | KPNA1 | ENSP00000394183 | ENSP00000343701 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and impo [...] | 0.416 |
| CDKN2AIPNL | OBSL1 | ENSP00000394183 | ENSP00000385636 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. | 0.457 |
| CDKN2AIPNL | RBM3 | ENSP00000394183 | ENSP00000365950 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | RNA-binding protein 3; Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). | 0.476 |
| CDKN2AIPNL | XRN2 | ENSP00000394183 | ENSP00000366396 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | 0.999 |
| CUL7 | CDKN2AIPNL | ENSP00000438788 | ENSP00000394183 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 0.457 |
| CUL7 | OBSL1 | ENSP00000438788 | ENSP00000385636 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. | 0.999 |
| CUL7 | XRN2 | ENSP00000438788 | ENSP00000366396 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | 0.550 |
| EID2B | CDKN2AIPNL | ENSP00000317564 | ENSP00000394183 | EP300-interacting inhibitor of differentiation 2B; Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation. | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 0.510 |
| IQCF6 | CDKN2AIPNL | ENSP00000381760 | ENSP00000394183 | IQ motif containing F6. | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 0.436 |
| KPNA1 | CDKN2AIPNL | ENSP00000343701 | ENSP00000394183 | Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and impo [...] | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 0.416 |
| KPNA1 | XRN2 | ENSP00000343701 | ENSP00000366396 | Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and impo [...] | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...] | 0.892 |
| OBSL1 | CDKN2AIPNL | ENSP00000385636 | ENSP00000394183 | Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like. | 0.457 |
