node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLDN20 | CNK3/IPCEF1 | ENSP00000356133 | ENSP00000499846 | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | 0.527 |
CLDN20 | CNKSR3 | ENSP00000356133 | ENSP00000475915 | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). | 0.559 |
CLDN20 | IPCEF1 | ENSP00000356133 | ENSP00000394751 | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Interaction protein for cytohesin exchange factors 1. | 0.527 |
CLDN20 | SCAF8 | ENSP00000356133 | ENSP00000413098 | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | SR-related and CTD-associated factor 8; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...] | 0.610 |
CLDN20 | TIAM2 | ENSP00000356133 | ENSP00000437188 | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | T-lymphoma invasion and metastasis-inducing protein 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling acc [...] | 0.603 |
CNK3/IPCEF1 | CLDN20 | ENSP00000499846 | ENSP00000356133 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.527 |
CNK3/IPCEF1 | CYTH1 | ENSP00000499846 | ENSP00000389095 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | 0.463 |
CNK3/IPCEF1 | CYTH2 | ENSP00000499846 | ENSP00000493357 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth (By similarity). | 0.748 |
CNK3/IPCEF1 | CYTH3 | ENSP00000499846 | ENSP00000297044 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). | 0.431 |
CNK3/IPCEF1 | CYTH4 | ENSP00000499846 | ENSP00000248901 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. | 0.475 |
CNK3/IPCEF1 | IPCEF1 | ENSP00000499846 | ENSP00000394751 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | Interaction protein for cytohesin exchange factors 1. | 0.800 |
CNK3/IPCEF1 | OPRM1 | ENSP00000499846 | ENSP00000394624 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] | 0.555 |
CNK3/IPCEF1 | SCAF8 | ENSP00000499846 | ENSP00000413098 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | SR-related and CTD-associated factor 8; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...] | 0.601 |
CNK3/IPCEF1 | TIAM2 | ENSP00000499846 | ENSP00000437188 | CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. | T-lymphoma invasion and metastasis-inducing protein 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling acc [...] | 0.538 |
CNKSR3 | CLDN20 | ENSP00000475915 | ENSP00000356133 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.559 |
CNKSR3 | CYTH2 | ENSP00000475915 | ENSP00000493357 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth (By similarity). | 0.650 |
CNKSR3 | IPCEF1 | ENSP00000475915 | ENSP00000394751 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). | Interaction protein for cytohesin exchange factors 1. | 0.749 |
CNKSR3 | OPRM1 | ENSP00000475915 | ENSP00000394624 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] | 0.471 |
CNKSR3 | SCAF8 | ENSP00000475915 | ENSP00000413098 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). | SR-related and CTD-associated factor 8; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...] | 0.665 |
CNKSR3 | TIAM2 | ENSP00000475915 | ENSP00000437188 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC). | T-lymphoma invasion and metastasis-inducing protein 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling acc [...] | 0.536 |