node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM185A | FBXL13 | ENSP00000395340 | ENSP00000321927 | Protein FAM185A; Family with sequence similarity 185 member A. | Dynein regulatory complex subunit 6; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the DRC6 family. | 0.543 |
FAM185A | PEX12 | ENSP00000395340 | ENSP00000482609 | Protein FAM185A; Family with sequence similarity 185 member A. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | 0.544 |
FAM185A | PEX13 | ENSP00000395340 | ENSP00000295030 | Protein FAM185A; Family with sequence similarity 185 member A. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. | 0.896 |
FAM185A | PEX19 | ENSP00000395340 | ENSP00000357051 | Protein FAM185A; Family with sequence similarity 185 member A. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.603 |
FAM185A | PEX2 | ENSP00000395340 | ENSP00000349543 | Protein FAM185A; Family with sequence similarity 185 member A. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.628 |
FAM185A | PEX5 | ENSP00000395340 | ENSP00000391601 | Protein FAM185A; Family with sequence similarity 185 member A. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.729 |
FAM185A | PEX5L | ENSP00000395340 | ENSP00000419975 | Protein FAM185A; Family with sequence similarity 185 member A. | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family. | 0.729 |
FAM185A | PEX6 | ENSP00000395340 | ENSP00000303511 | Protein FAM185A; Family with sequence similarity 185 member A. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.539 |
FAM185A | PEX7 | ENSP00000395340 | ENSP00000315680 | Protein FAM185A; Family with sequence similarity 185 member A. | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Belongs to the WD repeat peroxin-7 family. | 0.741 |
FAM185A | SPDYE17 | ENSP00000395340 | ENSP00000501047 | Protein FAM185A; Family with sequence similarity 185 member A. | Putative speedy protein E16; speedy/RINGO cell cycle regulator family member E17. | 0.599 |
FBXL13 | FAM185A | ENSP00000321927 | ENSP00000395340 | Dynein regulatory complex subunit 6; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the DRC6 family. | Protein FAM185A; Family with sequence similarity 185 member A. | 0.543 |
PEX12 | FAM185A | ENSP00000482609 | ENSP00000395340 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Protein FAM185A; Family with sequence similarity 185 member A. | 0.544 |
PEX12 | PEX13 | ENSP00000482609 | ENSP00000295030 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. | 0.999 |
PEX12 | PEX19 | ENSP00000482609 | ENSP00000357051 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.995 |
PEX12 | PEX2 | ENSP00000482609 | ENSP00000349543 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.999 |
PEX12 | PEX5 | ENSP00000482609 | ENSP00000391601 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.998 |
PEX12 | PEX5L | ENSP00000482609 | ENSP00000419975 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family. | 0.950 |
PEX12 | PEX6 | ENSP00000482609 | ENSP00000303511 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. | 0.988 |
PEX12 | PEX7 | ENSP00000482609 | ENSP00000315680 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Belongs to the WD repeat peroxin-7 family. | 0.986 |
PEX13 | FAM185A | ENSP00000295030 | ENSP00000395340 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins. | Protein FAM185A; Family with sequence similarity 185 member A. | 0.896 |