node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAG1 | DYTN | ENSP00000442600 | ENSP00000396593 | Dystroglycan 1; Dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | Dystrotelin; Zinc fingers ZZ-type | 0.617 |
DSCR3 | DYTN | ENSP00000311399 | ENSP00000396593 | VPS26 endosomal protein sorting factor C; Down syndrome critical region gene 3; Belongs to the VPS26 family | Dystrotelin; Zinc fingers ZZ-type | 0.719 |
DSCR3 | RAB11FIP3 | ENSP00000311399 | ENSP00000262305 | VPS26 endosomal protein sorting factor C; Down syndrome critical region gene 3; Belongs to the VPS26 family | Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive [...] | 0.419 |
DSCR3 | RAB11FIP4 | ENSP00000311399 | ENSP00000482620 | VPS26 endosomal protein sorting factor C; Down syndrome critical region gene 3; Belongs to the VPS26 family | Rab11 family-interacting protein 4; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6; EF-hand domain containing | 0.656 |
DYTN | DAG1 | ENSP00000396593 | ENSP00000442600 | Dystrotelin; Zinc fingers ZZ-type | Dystroglycan 1; Dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.617 |
DYTN | DSCR3 | ENSP00000396593 | ENSP00000311399 | Dystrotelin; Zinc fingers ZZ-type | VPS26 endosomal protein sorting factor C; Down syndrome critical region gene 3; Belongs to the VPS26 family | 0.719 |
DYTN | FASTKD2 | ENSP00000396593 | ENSP00000236980 | Dystrotelin; Zinc fingers ZZ-type | FAST kinase domain-containing protein 2, mitochondrial; Plays an important role in assembly of the mitochondrial large ribosomal subunit; FASTK mitochondrial RNA binding family | 0.626 |
DYTN | HSPBP1 | ENSP00000396593 | ENSP00000255631 | Dystrotelin; Zinc fingers ZZ-type | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR; Armadillo-like helical domain containing | 0.568 |
DYTN | LRRC38 | ENSP00000396593 | ENSP00000365253 | Dystrotelin; Zinc fingers ZZ-type | Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium | 0.536 |
DYTN | NOS1AP | ENSP00000396593 | ENSP00000355133 | Dystrotelin; Zinc fingers ZZ-type | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity) | 0.551 |
DYTN | OR3A2 | ENSP00000396593 | ENSP00000386180 | Dystrotelin; Zinc fingers ZZ-type | Olfactory receptor 3A2; Odorant receptor; Olfactory receptors, family 3 | 0.563 |
DYTN | RAB11FIP3 | ENSP00000396593 | ENSP00000262305 | Dystrotelin; Zinc fingers ZZ-type | Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive [...] | 0.704 |
DYTN | RAB11FIP4 | ENSP00000396593 | ENSP00000482620 | Dystrotelin; Zinc fingers ZZ-type | Rab11 family-interacting protein 4; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6; EF-hand domain containing | 0.772 |
DYTN | TOR1A | ENSP00000396593 | ENSP00000345719 | Dystrotelin; Zinc fingers ZZ-type | Torsin family 1 member a; Torsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates [...] | 0.566 |
FASTKD2 | DYTN | ENSP00000236980 | ENSP00000396593 | FAST kinase domain-containing protein 2, mitochondrial; Plays an important role in assembly of the mitochondrial large ribosomal subunit; FASTK mitochondrial RNA binding family | Dystrotelin; Zinc fingers ZZ-type | 0.626 |
HSPBP1 | DYTN | ENSP00000255631 | ENSP00000396593 | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR; Armadillo-like helical domain containing | Dystrotelin; Zinc fingers ZZ-type | 0.568 |
LRRC38 | DYTN | ENSP00000365253 | ENSP00000396593 | Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium | Dystrotelin; Zinc fingers ZZ-type | 0.536 |
NOS1AP | DYTN | ENSP00000355133 | ENSP00000396593 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity) | Dystrotelin; Zinc fingers ZZ-type | 0.551 |
OR3A2 | DYTN | ENSP00000386180 | ENSP00000396593 | Olfactory receptor 3A2; Odorant receptor; Olfactory receptors, family 3 | Dystrotelin; Zinc fingers ZZ-type | 0.563 |
RAB11FIP3 | DSCR3 | ENSP00000262305 | ENSP00000311399 | Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive [...] | VPS26 endosomal protein sorting factor C; Down syndrome critical region gene 3; Belongs to the VPS26 family | 0.419 |