MROH7 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP4	CAPZA3	ENSP00000351327	ENSP00000326238	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	0.783
AKAP4	CCIN	ENSP00000351327	ENSP00000334996	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation.	0.906
AKAP4	CFAP52	ENSP00000351327	ENSP00000339449	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family.	0.717
AKAP4	EFCAB6	ENSP00000351327	ENSP00000262726	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.	0.545
AKAP4	EFHC2	ENSP00000351327	ENSP00000404232	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	EF-hand domain-containing family member C2; EF-hand domain containing 2.	0.738
AKAP4	FAM166A	ENSP00000351327	ENSP00000344729	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	Protein FAM166A; Family with sequence similarity 166 member A.	0.732
AKAP4	MROH7	ENSP00000351327	ENSP00000396622	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	Maestro heat like repeat family member 7.	0.765
AKAP4	NUP210L	ENSP00000351327	ENSP00000357547	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family.	0.878
AKAP4	SPAG8	ENSP00000351327	ENSP00000340982	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.571
AKAP4	TEKT5	ENSP00000351327	ENSP00000283025	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	Tektin-5; May be a structural component of the sperm flagellum.	0.784
CAPZA3	AKAP4	ENSP00000326238	ENSP00000351327	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	0.783
CAPZA3	CCIN	ENSP00000326238	ENSP00000334996	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation.	0.791
CAPZA3	CFAP52	ENSP00000326238	ENSP00000339449	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family.	0.496
CAPZA3	EFCAB6	ENSP00000326238	ENSP00000262726	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.	0.649
CAPZA3	EFHC2	ENSP00000326238	ENSP00000404232	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	EF-hand domain-containing family member C2; EF-hand domain containing 2.	0.536
CAPZA3	FAM166A	ENSP00000326238	ENSP00000344729	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	Protein FAM166A; Family with sequence similarity 166 member A.	0.633
CAPZA3	MROH7	ENSP00000326238	ENSP00000396622	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	Maestro heat like repeat family member 7.	0.728
CAPZA3	NUP210L	ENSP00000326238	ENSP00000357547	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family.	0.557
CAPZA3	SPAG8	ENSP00000326238	ENSP00000340982	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.579
CAPZA3	TEKT5	ENSP00000326238	ENSP00000283025	F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	Tektin-5; May be a structural component of the sperm flagellum.	0.591