node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf62 | DNAJC11 | ENSP00000341178 | ENSP00000366800 | Uncharacterized protein C15orf62, mitochondrial; Chromosome 15 open reading frame 62. | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | 0.431 |
C15orf62 | DNAJC4 | ENSP00000341178 | ENSP00000320548 | Uncharacterized protein C15orf62, mitochondrial; Chromosome 15 open reading frame 62. | DnaJ heat shock protein family member C4. | 0.481 |
CDC5L | DNAJC4 | ENSP00000360532 | ENSP00000320548 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | DnaJ heat shock protein family member C4. | 0.492 |
DNAJC11 | C15orf62 | ENSP00000366800 | ENSP00000341178 | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | Uncharacterized protein C15orf62, mitochondrial; Chromosome 15 open reading frame 62. | 0.431 |
DNAJC11 | DNAJC24 | ENSP00000366800 | ENSP00000417548 | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family. | 0.441 |
DNAJC11 | DNAJC28 | ENSP00000366800 | ENSP00000479716 | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone. | 0.486 |
DNAJC11 | DNAJC4 | ENSP00000366800 | ENSP00000320548 | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | DnaJ heat shock protein family member C4. | 0.689 |
DNAJC11 | HSPA9 | ENSP00000366800 | ENSP00000297185 | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity). Belongs to the heat shock protein 70 family. | 0.950 |
DNAJC11 | MTX1 | ENSP00000366800 | ENSP00000357360 | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). | 0.949 |
DNAJC24 | DNAJC11 | ENSP00000417548 | ENSP00000366800 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family. | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | 0.441 |
DNAJC24 | DNAJC28 | ENSP00000417548 | ENSP00000479716 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family. | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone. | 0.610 |
DNAJC24 | DNAJC4 | ENSP00000417548 | ENSP00000320548 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family. | DnaJ heat shock protein family member C4. | 0.507 |
DNAJC24 | DNAJC9 | ENSP00000417548 | ENSP00000362041 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family. | DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. | 0.478 |
DNAJC24 | HSPA9 | ENSP00000417548 | ENSP00000297185 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity). Belongs to the heat shock protein 70 family. | 0.671 |
DNAJC28 | DNAJC11 | ENSP00000479716 | ENSP00000366800 | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone. | DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family. | 0.486 |
DNAJC28 | DNAJC24 | ENSP00000479716 | ENSP00000417548 | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone. | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family. | 0.610 |
DNAJC28 | DNAJC4 | ENSP00000479716 | ENSP00000320548 | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone. | DnaJ heat shock protein family member C4. | 0.503 |
DNAJC28 | DNAJC9 | ENSP00000479716 | ENSP00000362041 | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone. | DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. | 0.598 |
DNAJC4 | C15orf62 | ENSP00000320548 | ENSP00000341178 | DnaJ heat shock protein family member C4. | Uncharacterized protein C15orf62, mitochondrial; Chromosome 15 open reading frame 62. | 0.481 |
DNAJC4 | CDC5L | ENSP00000320548 | ENSP00000360532 | DnaJ heat shock protein family member C4. | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | 0.492 |