LRRN3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML5	LRRN3	ENSP00000369689	ENSP00000397312	Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes.	Leucine rich repeat neuronal 3.	0.415
CLDND1	GPR15	ENSP00000377735	ENSP00000284311	Claudin domain containing 1.	G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family.	0.492
CLDND1	LRRN3	ENSP00000377735	ENSP00000397312	Claudin domain containing 1.	Leucine rich repeat neuronal 3.	0.491
F2RL3	LRRN3	ENSP00000248076	ENSP00000397312	Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family.	Leucine rich repeat neuronal 3.	0.507
GPR15	CLDND1	ENSP00000284311	ENSP00000377735	G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family.	Claudin domain containing 1.	0.492
GPR15	LRRN3	ENSP00000284311	ENSP00000397312	G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family.	Leucine rich repeat neuronal 3.	0.570
IMMP2L	LRRN3	ENSP00000384966	ENSP00000397312	Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily.	Leucine rich repeat neuronal 3.	0.463
LRRC8D	LRRN3	ENSP00000338887	ENSP00000397312	Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel [...]	Leucine rich repeat neuronal 3.	0.467
LRRN3	CALML5	ENSP00000397312	ENSP00000369689	Leucine rich repeat neuronal 3.	Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes.	0.415
LRRN3	CLDND1	ENSP00000397312	ENSP00000377735	Leucine rich repeat neuronal 3.	Claudin domain containing 1.	0.491
LRRN3	F2RL3	ENSP00000397312	ENSP00000248076	Leucine rich repeat neuronal 3.	Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family.	0.507
LRRN3	GPR15	ENSP00000397312	ENSP00000284311	Leucine rich repeat neuronal 3.	G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family.	0.570
LRRN3	IMMP2L	ENSP00000397312	ENSP00000384966	Leucine rich repeat neuronal 3.	Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily.	0.463
LRRN3	LRRC8D	ENSP00000397312	ENSP00000338887	Leucine rich repeat neuronal 3.	Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel [...]	0.467
LRRN3	NELL2	ENSP00000397312	ENSP00000416341	Leucine rich repeat neuronal 3.	Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).	0.453
LRRN3	PID1	ENSP00000397312	ENSP00000283937	Leucine rich repeat neuronal 3.	PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation.	0.459
LRRN3	SASH1	ENSP00000397312	ENSP00000356437	Leucine rich repeat neuronal 3.	SAM and SH3 domain-containing protein 1; Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.	0.400
NELL2	LRRN3	ENSP00000416341	ENSP00000397312	Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).	Leucine rich repeat neuronal 3.	0.453
PID1	LRRN3	ENSP00000283937	ENSP00000397312	PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation.	Leucine rich repeat neuronal 3.	0.459
SASH1	LRRN3	ENSP00000356437	ENSP00000397312	SAM and SH3 domain-containing protein 1; Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.	Leucine rich repeat neuronal 3.	0.400