node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP9B | CWC22 | ENSP00000398076 | ENSP00000387006 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family | 0.515 |
ATP9B | ITFG1 | ENSP00000398076 | ENSP00000319918 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Integrin alpha fg-gap repeat containing protein 1; T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity); Belongs to the TIP family | 0.636 |
ATP9B | MON2 | ENSP00000398076 | ENSP00000377250 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.683 |
ATP9B | NEO1 | ENSP00000398076 | ENSP00000341198 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | 0.613 |
ATP9B | PQLC1 | ENSP00000398076 | ENSP00000380880 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.780 |
ATP9B | RTFDC1 | ENSP00000398076 | ENSP00000023939 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Protein RTF2 homolog; Replication termination factor 2 domain containing 1; Belongs to the rtf2 family | 0.601 |
ATP9B | TMEM30A | ENSP00000398076 | ENSP00000230461 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] | 0.786 |
ATP9B | TMEM30B | ENSP00000398076 | ENSP00000450842 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...] | 0.697 |
ATP9B | TMEM30C | ENSP00000398076 | ENSP00000419663 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Cell cycle control protein 50C; Transmembrane protein 30C; Belongs to the CDC50/LEM3 family | 0.762 |
ATP9B | ZFP64 | ENSP00000398076 | ENSP00000216923 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | Zinc finger protein 64 homolog, isoforms 1 and 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.557 |
CWC22 | ATP9B | ENSP00000387006 | ENSP00000398076 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | 0.515 |
ITFG1 | ATP9B | ENSP00000319918 | ENSP00000398076 | Integrin alpha fg-gap repeat containing protein 1; T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity); Belongs to the TIP family | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | 0.636 |
MON2 | ATP9B | ENSP00000377250 | ENSP00000398076 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | 0.683 |
MON2 | NEO1 | ENSP00000377250 | ENSP00000341198 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | 0.596 |
MON2 | TMEM30A | ENSP00000377250 | ENSP00000230461 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] | 0.433 |
MON2 | TMEM30B | ENSP00000377250 | ENSP00000450842 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...] | 0.400 |
MON2 | TMEM30C | ENSP00000377250 | ENSP00000419663 | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | Cell cycle control protein 50C; Transmembrane protein 30C; Belongs to the CDC50/LEM3 family | 0.427 |
NEO1 | ATP9B | ENSP00000341198 | ENSP00000398076 | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | 0.613 |
NEO1 | MON2 | ENSP00000341198 | ENSP00000377250 | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response; Belongs to the immunoglobulin superfamily. DCC family | MON2 homolog, regulator of endosome-to-Golgi trafficking; Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.596 |
PQLC1 | ATP9B | ENSP00000380880 | ENSP00000398076 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | 0.780 |