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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM243Transmembrane protein 243; Belongs to the TMEM243 family. (118 aa)    
Predicted Functional Partners:
DMTF1
Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53- dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
   
  
 0.619
RUNDC3B
RUN domain containing 3B.
      
 0.582
SLC25A40
Solute carrier family 25 member 40.
   
  
 0.513
FAM237B
Protein FAM237B; Family with sequence similarity 237 member B.
      
 0.474
MICOS10
MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
      
 0.435
KIAA1324L
UPF0577 protein KIAA1324-like; Belongs to the UPF0577 family.
   
  
 0.415
DCUN1D5
DCN1-like protein 5; Defective in cullin neddylation 1 domain containing 5.
   
  
 0.412
OR2F1
Olfactory receptor 2F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.406
FAM151B
Protein FAM151B; Family with sequence similarity 151 member B.
      
 0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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