node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD52 | FAM133B | ENSP00000267116 | ENSP00000398401 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. | Protein FAM133B; Family with sequence similarity 133 member B. | 0.476 |
CDK6 | FAM133B | ENSP00000265734 | ENSP00000398401 | Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...] | Protein FAM133B; Family with sequence similarity 133 member B. | 0.522 |
CDK6 | HEPACAM2 | ENSP00000265734 | ENSP00000390204 | Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...] | HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma- tubulin ring complex and promotes centrosome maturation. | 0.473 |
DNAJC2 | FAM133B | ENSP00000368565 | ENSP00000398401 | DnaJ homolog subfamily C member 2, N-terminally processed; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifi [...] | Protein FAM133B; Family with sequence similarity 133 member B. | 0.624 |
FAM133B | ANKRD52 | ENSP00000398401 | ENSP00000267116 | Protein FAM133B; Family with sequence similarity 133 member B. | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. | 0.476 |
FAM133B | CDK6 | ENSP00000398401 | ENSP00000265734 | Protein FAM133B; Family with sequence similarity 133 member B. | Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...] | 0.522 |
FAM133B | DNAJC2 | ENSP00000398401 | ENSP00000368565 | Protein FAM133B; Family with sequence similarity 133 member B. | DnaJ homolog subfamily C member 2, N-terminally processed; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifi [...] | 0.624 |
FAM133B | FAM204A | ENSP00000398401 | ENSP00000358183 | Protein FAM133B; Family with sequence similarity 133 member B. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.496 |
FAM133B | FAM98C | ENSP00000398401 | ENSP00000252530 | Protein FAM133B; Family with sequence similarity 133 member B. | Protein FAM98C; Family with sequence similarity 98 member C. | 0.475 |
FAM133B | GATAD1 | ENSP00000398401 | ENSP00000287957 | Protein FAM133B; Family with sequence similarity 133 member B. | GATA zinc finger domain-containing protein 1; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). | 0.488 |
FAM133B | HEPACAM2 | ENSP00000398401 | ENSP00000390204 | Protein FAM133B; Family with sequence similarity 133 member B. | HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma- tubulin ring complex and promotes centrosome maturation. | 0.483 |
FAM133B | RBM48 | ENSP00000398401 | ENSP00000265732 | Protein FAM133B; Family with sequence similarity 133 member B. | RNA binding motif protein 48; Belongs to the RBM48 family. | 0.552 |
FAM133B | RSRC2 | ENSP00000398401 | ENSP00000330188 | Protein FAM133B; Family with sequence similarity 133 member B. | Arginine and serine rich coiled-coil 2; Belongs to the RSRC2 family. | 0.521 |
FAM133B | VPS50 | ENSP00000398401 | ENSP00000307666 | Protein FAM133B; Family with sequence similarity 133 member B. | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). | 0.477 |
FAM204A | FAM133B | ENSP00000358183 | ENSP00000398401 | Protein FAM204A; Family with sequence similarity 204 member A. | Protein FAM133B; Family with sequence similarity 133 member B. | 0.496 |
FAM98C | FAM133B | ENSP00000252530 | ENSP00000398401 | Protein FAM98C; Family with sequence similarity 98 member C. | Protein FAM133B; Family with sequence similarity 133 member B. | 0.475 |
GATAD1 | FAM133B | ENSP00000287957 | ENSP00000398401 | GATA zinc finger domain-containing protein 1; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). | Protein FAM133B; Family with sequence similarity 133 member B. | 0.488 |
GATAD1 | RBM48 | ENSP00000287957 | ENSP00000265732 | GATA zinc finger domain-containing protein 1; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). | RNA binding motif protein 48; Belongs to the RBM48 family. | 0.527 |
HEPACAM2 | CDK6 | ENSP00000390204 | ENSP00000265734 | HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma- tubulin ring complex and promotes centrosome maturation. | Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...] | 0.473 |
HEPACAM2 | FAM133B | ENSP00000390204 | ENSP00000398401 | HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma- tubulin ring complex and promotes centrosome maturation. | Protein FAM133B; Family with sequence similarity 133 member B. | 0.483 |