node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL10 | ARL13A | ENSP00000308496 | ENSP00000398637 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family. | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | 0.548 |
ARL10 | ARL16 | ENSP00000308496 | ENSP00000380635 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family. | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16. | 0.659 |
ARL13A | ARL10 | ENSP00000398637 | ENSP00000308496 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family. | 0.548 |
ARL13A | ARL16 | ENSP00000398637 | ENSP00000380635 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16. | 0.684 |
ARL13A | CYLC1 | ENSP00000398637 | ENSP00000331556 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | 0.489 |
ARL13A | IFT27 | ENSP00000398637 | ENSP00000393541 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a rol [...] | 0.472 |
ARL13A | IFT88 | ENSP00000398637 | ENSP00000323580 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. | 0.559 |
ARL13A | KIF17 | ENSP00000398637 | ENSP00000247986 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Kinesin-like protein KIF17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.528 |
ARL13A | NPHP4 | ENSP00000398637 | ENSP00000367398 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subce [...] | 0.512 |
ARL13A | PDE6D | ENSP00000398637 | ENSP00000287600 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasin [...] | 0.490 |
ARL13A | RAB23 | ENSP00000398637 | ENSP00000417610 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 pr [...] | 0.464 |
ARL13A | TBCD | ENSP00000398637 | ENSP00000347719 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | 0.741 |
ARL16 | ARL10 | ENSP00000380635 | ENSP00000308496 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16. | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family. | 0.659 |
ARL16 | ARL13A | ENSP00000380635 | ENSP00000398637 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16. | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | 0.684 |
ARL16 | PDE6D | ENSP00000380635 | ENSP00000287600 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasin [...] | 0.782 |
CYLC1 | ARL13A | ENSP00000331556 | ENSP00000398637 | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | 0.489 |
IFT27 | ARL13A | ENSP00000393541 | ENSP00000398637 | Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a rol [...] | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | 0.472 |
IFT27 | IFT88 | ENSP00000393541 | ENSP00000323580 | Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a rol [...] | Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. | 0.999 |
IFT27 | KIF17 | ENSP00000393541 | ENSP00000247986 | Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a rol [...] | Kinesin-like protein KIF17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.534 |
IFT88 | ARL13A | ENSP00000323580 | ENSP00000398637 | Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A. | 0.559 |