node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP4 | FCHO1 | ENSP00000359045 | ENSP00000473001 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | 0.457 |
ARHGAP4 | FCHSD1 | ENSP00000359045 | ENSP00000399259 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.576 |
ARHGAP4 | FNBP1 | ENSP00000359045 | ENSP00000413625 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | Formin-binding protein 1; May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane [...] | 0.452 |
ARHGAP4 | TRIP10 | ENSP00000359045 | ENSP00000320117 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | Cdc42-interacting protein 4; Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form en [...] | 0.452 |
ARHGAP4 | WAS | ENSP00000359045 | ENSP00000365891 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | Wiskott-Aldrich syndrome protein; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) r [...] | 0.717 |
ARHGAP4 | WASL | ENSP00000359045 | ENSP00000223023 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a [...] | 0.526 |
FCHO1 | ARHGAP4 | ENSP00000473001 | ENSP00000359045 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | 0.457 |
FCHO1 | FCHSD1 | ENSP00000473001 | ENSP00000399259 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.622 |
FCHO1 | FNBP1 | ENSP00000473001 | ENSP00000413625 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | Formin-binding protein 1; May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane [...] | 0.856 |
FCHO1 | ITSN2 | ENSP00000473001 | ENSP00000347244 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.998 |
FCHO1 | SNX9 | ENSP00000473001 | ENSP00000376024 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin- independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promo [...] | 0.795 |
FCHO1 | TRIP10 | ENSP00000473001 | ENSP00000320117 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | Cdc42-interacting protein 4; Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form en [...] | 0.963 |
FCHO1 | WAS | ENSP00000473001 | ENSP00000365891 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | Wiskott-Aldrich syndrome protein; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) r [...] | 0.479 |
FCHO1 | WASL | ENSP00000473001 | ENSP00000223023 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a [...] | 0.749 |
FCHSD1 | ARHGAP4 | ENSP00000399259 | ENSP00000359045 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | 0.576 |
FCHSD1 | FCHO1 | ENSP00000399259 | ENSP00000473001 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. | 0.622 |
FCHSD1 | FNBP1 | ENSP00000399259 | ENSP00000413625 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Formin-binding protein 1; May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane [...] | 0.672 |
FCHSD1 | ITSN2 | ENSP00000399259 | ENSP00000347244 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.617 |
FCHSD1 | NCKIPSD | ENSP00000399259 | ENSP00000294129 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | NCK-interacting protein with SH3 domain; Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. | 0.610 |
FCHSD1 | SNX16 | ENSP00000399259 | ENSP00000379621 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm; Belongs to the sorting nexin family. | 0.599 |