C3orf52 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3orf52	LIPH	ENSP00000399392	ENSP00000296252	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Belongs to the AB hydrolase superfamily. Lipase family.	0.760
C3orf52	RBM14-RBM4	ENSP00000399392	ENSP00000388552	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	RBM14-RBM4 readthrough.	0.512
C3orf52	SIGLECL1	ENSP00000399392	ENSP00000321249	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	SIGLEC family like 1.	0.438
C3orf52	TMEM200A	ENSP00000399392	ENSP00000376224	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	Transmembrane protein 200A; Belongs to the TMEM200 family.	0.446
C3orf52	TMEM30B	ENSP00000399392	ENSP00000450842	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...]	0.401
C3orf52	TMPRSS2	ENSP00000399392	ENSP00000381588	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	Transmembrane protease serine 2 non-catalytic chain; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike gl [...]	0.844
LIPH	C3orf52	ENSP00000296252	ENSP00000399392	Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Belongs to the AB hydrolase superfamily. Lipase family.	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	0.760
RBM14-RBM4	C3orf52	ENSP00000388552	ENSP00000399392	RBM14-RBM4 readthrough.	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	0.512
SIGLECL1	C3orf52	ENSP00000321249	ENSP00000399392	SIGLEC family like 1.	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	0.438
TMEM200A	C3orf52	ENSP00000376224	ENSP00000399392	Transmembrane protein 200A; Belongs to the TMEM200 family.	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	0.446
TMEM30B	C3orf52	ENSP00000450842	ENSP00000399392	Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...]	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	0.401
TMPRSS2	C3orf52	ENSP00000381588	ENSP00000399392	Transmembrane protease serine 2 non-catalytic chain; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike gl [...]	TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.	0.844