node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT1 | CNP | ENSP00000311224 | ENSP00000377470 | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20); Belongs to the C/M/P thioester hydrolase family. | 2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. | 0.490 |
ACOT1 | ZFP69B | ENSP00000311224 | ENSP00000354547 | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20); Belongs to the C/M/P thioester hydrolase family. | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.535 |
C16orf96 | ZFP69B | ENSP00000415027 | ENSP00000354547 | Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96. | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.462 |
C3orf70 | ELFN2 | ENSP00000334974 | ENSP00000385277 | UPF0524 protein C3orf70; May play a role in neuronal and neurobehavioral development. | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. | 0.414 |
C3orf70 | ZFP69B | ENSP00000334974 | ENSP00000354547 | UPF0524 protein C3orf70; May play a role in neuronal and neurobehavioral development. | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.507 |
CNP | ACOT1 | ENSP00000377470 | ENSP00000311224 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20); Belongs to the C/M/P thioester hydrolase family. | 0.490 |
CNP | ZFP69B | ENSP00000377470 | ENSP00000354547 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.511 |
ELFN2 | C3orf70 | ENSP00000385277 | ENSP00000334974 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. | UPF0524 protein C3orf70; May play a role in neuronal and neurobehavioral development. | 0.414 |
ELFN2 | ZFP69B | ENSP00000385277 | ENSP00000354547 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.425 |
KCTD16 | SMAD3 | ENSP00000426548 | ENSP00000332973 | BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.577 |
KCTD16 | ZFP69B | ENSP00000426548 | ENSP00000354547 | BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.610 |
POC1A | ZFP69B | ENSP00000296484 | ENSP00000354547 | POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation; Belongs to the WD repeat POC1 family. | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.414 |
SMAD3 | KCTD16 | ENSP00000332973 | ENSP00000426548 | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). | 0.577 |
SMAD3 | ZFP69B | ENSP00000332973 | ENSP00000354547 | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.618 |
SMAP2 | ZFP69B | ENSP00000361803 | ENSP00000354547 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.513 |
TRIM28 | ZFP69B | ENSP00000253024 | ENSP00000354547 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 0.554 |
ZFP69B | ACOT1 | ENSP00000354547 | ENSP00000311224 | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20); Belongs to the C/M/P thioester hydrolase family. | 0.535 |
ZFP69B | C16orf96 | ENSP00000354547 | ENSP00000415027 | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96. | 0.462 |
ZFP69B | C3orf70 | ENSP00000354547 | ENSP00000334974 | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | UPF0524 protein C3orf70; May play a role in neuronal and neurobehavioral development. | 0.507 |
ZFP69B | CNP | ENSP00000354547 | ENSP00000377470 | Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity. | 2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. | 0.511 |