node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CFAP58 | FLYWCH1 | ENSP00000358718 | ENSP00000253928 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family. | FLYWCH-type zinc finger 1. | 0.458 |
FAM160B2 | FLYWCH1 | ENSP00000289921 | ENSP00000253928 | Protein FAM160B2; Family with sequence similarity 160 member B2; Belongs to the UPF0518 family. | FLYWCH-type zinc finger 1. | 0.478 |
FLYWCH1 | CFAP58 | ENSP00000253928 | ENSP00000358718 | FLYWCH-type zinc finger 1. | Cilia and flagella associated protein 58; Belongs to the CFAP58 family. | 0.458 |
FLYWCH1 | FAM160B2 | ENSP00000253928 | ENSP00000289921 | FLYWCH-type zinc finger 1. | Protein FAM160B2; Family with sequence similarity 160 member B2; Belongs to the UPF0518 family. | 0.478 |
FLYWCH1 | IFNAR2 | ENSP00000253928 | ENSP00000343957 | FLYWCH-type zinc finger 1. | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. | 0.490 |
FLYWCH1 | INPP5E | ENSP00000253928 | ENSP00000360777 | FLYWCH-type zinc finger 1. | Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity); Belongs to the in [...] | 0.556 |
FLYWCH1 | KLHL26 | ENSP00000253928 | ENSP00000300976 | FLYWCH-type zinc finger 1. | Kelch-like protein 26; Kelch like family member 26. | 0.446 |
FLYWCH1 | KREMEN2 | ENSP00000253928 | ENSP00000304422 | FLYWCH-type zinc finger 1. | Kremen protein 2; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. | 0.446 |
FLYWCH1 | MDC1 | ENSP00000253928 | ENSP00000365588 | FLYWCH-type zinc finger 1. | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be ac [...] | 0.469 |
FLYWCH1 | PAQR4 | ENSP00000253928 | ENSP00000321804 | FLYWCH-type zinc finger 1. | Progestin and adipoQ receptor family member 4. | 0.606 |
FLYWCH1 | RERGL | ENSP00000253928 | ENSP00000229002 | FLYWCH-type zinc finger 1. | Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity. | 0.443 |
FLYWCH1 | SNX15 | ENSP00000253928 | ENSP00000366452 | FLYWCH-type zinc finger 1. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.445 |
IFNAR2 | FLYWCH1 | ENSP00000343957 | ENSP00000253928 | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. | FLYWCH-type zinc finger 1. | 0.490 |
INPP5E | FLYWCH1 | ENSP00000360777 | ENSP00000253928 | Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity); Belongs to the in [...] | FLYWCH-type zinc finger 1. | 0.556 |
KLHL26 | FLYWCH1 | ENSP00000300976 | ENSP00000253928 | Kelch-like protein 26; Kelch like family member 26. | FLYWCH-type zinc finger 1. | 0.446 |
KREMEN2 | FLYWCH1 | ENSP00000304422 | ENSP00000253928 | Kremen protein 2; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. | FLYWCH-type zinc finger 1. | 0.446 |
MDC1 | FLYWCH1 | ENSP00000365588 | ENSP00000253928 | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be ac [...] | FLYWCH-type zinc finger 1. | 0.469 |
PAQR4 | FLYWCH1 | ENSP00000321804 | ENSP00000253928 | Progestin and adipoQ receptor family member 4. | FLYWCH-type zinc finger 1. | 0.606 |
RERGL | FLYWCH1 | ENSP00000229002 | ENSP00000253928 | Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity. | FLYWCH-type zinc finger 1. | 0.443 |
SNX15 | FLYWCH1 | ENSP00000366452 | ENSP00000253928 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | FLYWCH-type zinc finger 1. | 0.445 |