node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD13B | PRSS48 | ENSP00000378328 | ENSP00000401328 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Serine protease 48; Belongs to the peptidase S1 family. | 0.472 |
AP5B1 | PRSS48 | ENSP00000454303 | ENSP00000401328 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Serine protease 48; Belongs to the peptidase S1 family. | 0.438 |
CPAMD8 | PRSS48 | ENSP00000498697 | ENSP00000401328 | C3 and PZP like alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. | Serine protease 48; Belongs to the peptidase S1 family. | 0.425 |
CRYBG2 | PRSS48 | ENSP00000428746 | ENSP00000401328 | Beta/gamma crystallin domain-containing protein 2; Crystallin beta-gamma domain containing 2; Belongs to the beta/gamma-crystallin family. | Serine protease 48; Belongs to the peptidase S1 family. | 0.445 |
CWC22 | PRSS48 | ENSP00000387006 | ENSP00000401328 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | Serine protease 48; Belongs to the peptidase S1 family. | 0.442 |
NOS1AP | PRSS48 | ENSP00000355133 | ENSP00000401328 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | Serine protease 48; Belongs to the peptidase S1 family. | 0.494 |
OR11G2 | PRSS48 | ENSP00000349930 | ENSP00000401328 | Olfactory receptor 11G2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Serine protease 48; Belongs to the peptidase S1 family. | 0.576 |
PRSS48 | ANKRD13B | ENSP00000401328 | ENSP00000378328 | Serine protease 48; Belongs to the peptidase S1 family. | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.472 |
PRSS48 | AP5B1 | ENSP00000401328 | ENSP00000454303 | Serine protease 48; Belongs to the peptidase S1 family. | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | 0.438 |
PRSS48 | CPAMD8 | ENSP00000401328 | ENSP00000498697 | Serine protease 48; Belongs to the peptidase S1 family. | C3 and PZP like alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. | 0.425 |
PRSS48 | CRYBG2 | ENSP00000401328 | ENSP00000428746 | Serine protease 48; Belongs to the peptidase S1 family. | Beta/gamma crystallin domain-containing protein 2; Crystallin beta-gamma domain containing 2; Belongs to the beta/gamma-crystallin family. | 0.445 |
PRSS48 | CWC22 | ENSP00000401328 | ENSP00000387006 | Serine protease 48; Belongs to the peptidase S1 family. | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | 0.442 |
PRSS48 | NOS1AP | ENSP00000401328 | ENSP00000355133 | Serine protease 48; Belongs to the peptidase S1 family. | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | 0.494 |
PRSS48 | OR11G2 | ENSP00000401328 | ENSP00000349930 | Serine protease 48; Belongs to the peptidase S1 family. | Olfactory receptor 11G2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.576 |
PRSS48 | SH3D19 | ENSP00000401328 | ENSP00000302913 | Serine protease 48; Belongs to the peptidase S1 family. | SH3 domain-containing protein 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.663 |
PRSS48 | TRIM68 | ENSP00000401328 | ENSP00000300747 | Serine protease 48; Belongs to the peptidase S1 family. | E3 ubiquitin-protein ligase TRIM68; Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. | 0.475 |
PRSS48 | WFDC3 | ENSP00000401328 | ENSP00000243938 | Serine protease 48; Belongs to the peptidase S1 family. | WAP four-disulfide core domain 3. | 0.469 |
SH3D19 | PRSS48 | ENSP00000302913 | ENSP00000401328 | SH3 domain-containing protein 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. | Serine protease 48; Belongs to the peptidase S1 family. | 0.663 |
TRIM68 | PRSS48 | ENSP00000300747 | ENSP00000401328 | E3 ubiquitin-protein ligase TRIM68; Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. | Serine protease 48; Belongs to the peptidase S1 family. | 0.475 |
WFDC3 | PRSS48 | ENSP00000243938 | ENSP00000401328 | WAP four-disulfide core domain 3. | Serine protease 48; Belongs to the peptidase S1 family. | 0.469 |