node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKFN1 | C17orf58 | ENSP00000321627 | ENSP00000402020 | Ankyrin repeat and fibronectin type III domain containing 1. | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | 0.447 |
ANKFN1 | SLC35G1 | ENSP00000321627 | ENSP00000400932 | Ankyrin repeat and fibronectin type III domain containing 1. | Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. | 0.474 |
BPTF | C17orf58 | ENSP00000307208 | ENSP00000402020 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | 0.517 |
BPTF | PBRM1 | ENSP00000307208 | ENSP00000386593 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | Protein polybromo-1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. | 0.500 |
C17orf58 | ANKFN1 | ENSP00000402020 | ENSP00000321627 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | Ankyrin repeat and fibronectin type III domain containing 1. | 0.447 |
C17orf58 | BPTF | ENSP00000402020 | ENSP00000307208 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | 0.517 |
C17orf58 | C1QTNF4 | ENSP00000402020 | ENSP00000302274 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | Complement C1q tumor necrosis factor-related protein 4; May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity). | 0.428 |
C17orf58 | MYSM1 | ENSP00000402020 | ENSP00000418734 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | 0.588 |
C17orf58 | OR7D2 | ENSP00000402020 | ENSP00000493200 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | Olfactory receptor 7D2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.400 |
C17orf58 | PBRM1 | ENSP00000402020 | ENSP00000386593 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | Protein polybromo-1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. | 0.511 |
C17orf58 | SLC35G1 | ENSP00000402020 | ENSP00000400932 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. | 0.441 |
C17orf58 | SMARCB1 | ENSP00000402020 | ENSP00000340883 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric struct [...] | 0.541 |
C17orf58 | SMARCE1 | ENSP00000402020 | ENSP00000323967 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Du [...] | 0.446 |
C1QTNF4 | C17orf58 | ENSP00000302274 | ENSP00000402020 | Complement C1q tumor necrosis factor-related protein 4; May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity). | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | 0.428 |
MYSM1 | C17orf58 | ENSP00000418734 | ENSP00000402020 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | 0.588 |
MYSM1 | PBRM1 | ENSP00000418734 | ENSP00000386593 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | Protein polybromo-1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. | 0.914 |
MYSM1 | SMARCB1 | ENSP00000418734 | ENSP00000340883 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric struct [...] | 0.851 |
MYSM1 | SMARCE1 | ENSP00000418734 | ENSP00000323967 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Du [...] | 0.648 |
OR7D2 | C17orf58 | ENSP00000493200 | ENSP00000402020 | Olfactory receptor 7D2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58. | 0.400 |
PBRM1 | BPTF | ENSP00000386593 | ENSP00000307208 | Protein polybromo-1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | 0.500 |