STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IQCJIQ motif containing J. (159 aa)    
Predicted Functional Partners:
SCHIP1
Schwannomin interacting protein 1.
 
    
 0.985
NRGN
NEUG(55-78); Acts as a 'third messenger' substrate of protein kinase C- mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). Belongs to the neurogranin family.
      
 0.750
GAP43
Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
      
 0.590
PRR23A
Proline-rich protein 23A; Proline rich 23A; Belongs to the PRR23 family.
      
 0.583
NF2
Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...]
    
 
 0.576
EXOC3L4
Exocyst complex component 3 like 4; Belongs to the SEC6 family.
   
  
 0.481
C11orf53
Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.
      
 0.480
HEATR5A
HEAT repeat containing 5A.
      
 0.461
NXPH1
Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.
   
  
 0.448
CCDC113
Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.
      
 0.434
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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