STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIM48Tripartite motif containing 48; Belongs to the TRIM/RBCC family. (224 aa)    
Predicted Functional Partners:
PRAMEF13
PRAME family member 13; Belongs to the PRAME family.
   
 
 0.545
PRAMEF11
PRAME family member 11; Belongs to the PRAME family.
   
 
 0.533
PRAMEF1
PRAME family member 1; Belongs to the PRAME family.
   
 
 0.525
STAT1
Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF [...]
     
 0.521
OR8J3
Olfactory receptor 8J3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.505
KHDC1L
Putative KHDC1-like protein; KH domain containing 1 like; Belongs to the KHDC1 family.
      
 0.479
OR5F1
Olfactory receptor 5F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.476
RFPL2
Ret finger protein like 2.
   
  
 0.475
OR5D16
Olfactory receptor 5D16; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.469
OR4A15
Olfactory receptor 4A15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.448
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.