STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM177Transmembrane protein 177 (311 aa)    
Predicted Functional Partners:
MRPL45
Mitochondrial ribosomal protein L45
   
   0.824
MRPL50
Mitochondrial ribosomal protein L50
    
   0.821
MRPL19
Mitochondrial ribosomal protein L19; Belongs to the bacterial ribosomal protein bL19 family
   
   0.821
MRPL38
Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily
    
   0.819
MRPL24
Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family
   
   0.806
TSR1
Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus
   
   0.804
MRPL11
Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family
   
   0.804
GADD45GIP1
Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis
    
   0.802
MRPL51
Mitochondrial ribosomal protein L51; Belongs to the mitochondrion-specific ribosomal protein mL51 family
   
   0.794
MRPL16
Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family
   
   0.789
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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