C2orf74 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2orf74	FAM161A	ENSP00000398725	ENSP00000385158	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Protein FAM161A; Involved in ciliogenesis.	0.408
C2orf74	FAM162B	ENSP00000398725	ENSP00000357545	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Protein FAM162B; Family with sequence similarity 162 member B.	0.493
C2orf74	KIAA1841	ENSP00000398725	ENSP00000385579	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Uncharacterized protein KIAA1841; KIAA1841.	0.700
C2orf74	MINDY4	ENSP00000398725	ENSP00000265299	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 subfamily.	0.439
C2orf74	NPIPB8	ENSP00000398725	ENSP00000434399	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Nuclear pore complex interacting protein family member B8; Belongs to the NPIP family.	0.421
C2orf74	PUS10	ENSP00000398725	ENSP00000326003	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.	0.442
C2orf74	SIRPD	ENSP00000398725	ENSP00000371036	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Signal regulatory protein delta.	0.497
C2orf74	TRIM21	ENSP00000398725	ENSP00000254436	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degrad [...]	0.457
C2orf74	UBE2H	ENSP00000398725	ENSP00000347836	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.	0.457
FAM161A	C2orf74	ENSP00000385158	ENSP00000398725	Protein FAM161A; Involved in ciliogenesis.	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	0.408
FAM162B	C2orf74	ENSP00000357545	ENSP00000398725	Protein FAM162B; Family with sequence similarity 162 member B.	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	0.493
FAM162B	KIAA1841	ENSP00000357545	ENSP00000385579	Protein FAM162B; Family with sequence similarity 162 member B.	Uncharacterized protein KIAA1841; KIAA1841.	0.492
FAM162B	SIRPD	ENSP00000357545	ENSP00000371036	Protein FAM162B; Family with sequence similarity 162 member B.	Signal regulatory protein delta.	0.443
KIAA1841	C2orf74	ENSP00000385579	ENSP00000398725	Uncharacterized protein KIAA1841; KIAA1841.	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	0.700
KIAA1841	FAM162B	ENSP00000385579	ENSP00000357545	Uncharacterized protein KIAA1841; KIAA1841.	Protein FAM162B; Family with sequence similarity 162 member B.	0.492
KIAA1841	MINDY4	ENSP00000385579	ENSP00000265299	Uncharacterized protein KIAA1841; KIAA1841.	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 subfamily.	0.409
KIAA1841	PUS10	ENSP00000385579	ENSP00000326003	Uncharacterized protein KIAA1841; KIAA1841.	Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.	0.554
KIAA1841	SIRPD	ENSP00000385579	ENSP00000371036	Uncharacterized protein KIAA1841; KIAA1841.	Signal regulatory protein delta.	0.470
MINDY4	C2orf74	ENSP00000265299	ENSP00000398725	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 subfamily.	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.	0.439
MINDY4	KIAA1841	ENSP00000265299	ENSP00000385579	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 subfamily.	Uncharacterized protein KIAA1841; KIAA1841.	0.409