C10orf105 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf105	CDH23	ENSP00000403151	ENSP00000224721	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.	0.414
C10orf105	EGFL8	ENSP00000403151	ENSP00000378888	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	Epidermal growth factor-like protein 8; EGF like domain multiple 8.	0.499
C10orf105	PPT2	ENSP00000403151	ENSP00000354608	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.	0.465
C10orf105	RNF39	ENSP00000403151	ENSP00000244360	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance.	0.498
CDH23	C10orf105	ENSP00000224721	ENSP00000403151	Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	0.414
EGFL8	C10orf105	ENSP00000378888	ENSP00000403151	Epidermal growth factor-like protein 8; EGF like domain multiple 8.	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	0.499
EGFL8	PPT2	ENSP00000378888	ENSP00000354608	Epidermal growth factor-like protein 8; EGF like domain multiple 8.	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.	0.690
PPT2	C10orf105	ENSP00000354608	ENSP00000403151	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	0.465
PPT2	EGFL8	ENSP00000354608	ENSP00000378888	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.	Epidermal growth factor-like protein 8; EGF like domain multiple 8.	0.690
RNF39	C10orf105	ENSP00000244360	ENSP00000403151	RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance.	Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.	0.498