Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
ER membrane protein complex subunit 9 (208 aa)
Predicted Functional Partners:
ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing (297 aa)
ER membrane protein complex subunit 3 (261 aa)
ER membrane protein complex subunit 1; Belongs to the EMC1 family (993 aa)
ER membrane protein complex subunit 10; Belongs to the EMC10 family (262 aa)
ER membrane protein complex subunit 6; Belongs to the EMC6 family (110 aa)
ER membrane protein complex subunit 4; May mediate anti-apoptotic activity (183 aa)
Membrane magnesium transporter 1; Mediates Mg(2+) transport; Belongs to the membrane magnesium transporter (TC 1.A.67) family (131 aa)
ER membrane protein complex subunit 7 (242 aa)
ER membrane protein complex subunit 8 (210 aa)
Mortality factor 4-like protein 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] (362 aa)
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NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo sapiens, human, man