node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HEMK1 | TBCEL | ENSP00000404843 | ENSP00000403925 | MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.461 |
MITD1 | TBCEL | ENSP00000289359 | ENSP00000403925 | MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.513 |
PIP5K1B | TBCEL | ENSP00000265382 | ENSP00000403925 | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.486 |
RPP38 | TBCEL | ENSP00000478982 | ENSP00000403925 | Ribonuclease P protein subunit p38; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre- rRNA sequences. Belongs to the eukaryotic ribosomal protein eL8 family. | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.448 |
TBCA | TBCB | ENSP00000306362 | ENSP00000221855 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway. | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). Belongs to the TBCB family. | 0.717 |
TBCA | TBCC | ENSP00000306362 | ENSP00000361967 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway. | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. | 0.695 |
TBCA | TBCD | ENSP00000306362 | ENSP00000347719 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway. | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | 0.816 |
TBCA | TBCEL | ENSP00000306362 | ENSP00000403925 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway. | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.512 |
TBCB | TBCA | ENSP00000221855 | ENSP00000306362 | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). Belongs to the TBCB family. | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway. | 0.717 |
TBCB | TBCC | ENSP00000221855 | ENSP00000361967 | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). Belongs to the TBCB family. | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. | 0.743 |
TBCB | TBCD | ENSP00000221855 | ENSP00000347719 | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). Belongs to the TBCB family. | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | 0.903 |
TBCB | TBCEL | ENSP00000221855 | ENSP00000403925 | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). Belongs to the TBCB family. | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.486 |
TBCC | TBCA | ENSP00000361967 | ENSP00000306362 | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway. | 0.695 |
TBCC | TBCB | ENSP00000361967 | ENSP00000221855 | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). Belongs to the TBCB family. | 0.743 |
TBCC | TBCD | ENSP00000361967 | ENSP00000347719 | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | 0.878 |
TBCC | TBCEL | ENSP00000361967 | ENSP00000403925 | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.588 |
TBCD | TBCA | ENSP00000347719 | ENSP00000306362 | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway. | 0.816 |
TBCD | TBCB | ENSP00000347719 | ENSP00000221855 | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). Belongs to the TBCB family. | 0.903 |
TBCD | TBCC | ENSP00000347719 | ENSP00000361967 | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. | 0.878 |
TBCD | TBCEL | ENSP00000347719 | ENSP00000403925 | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. | 0.889 |