EFCAB3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC105	EFCAB3	ENSP00000292574	ENSP00000403932	Coiled-coil domain containing 105.	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	0.868
CCDC105	EFCAB6	ENSP00000292574	ENSP00000262726	Coiled-coil domain containing 105.	EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.	0.958
CCDC105	EFHB	ENSP00000292574	ENSP00000295824	Coiled-coil domain containing 105.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.986
CCDC105	EFHC1	ENSP00000292574	ENSP00000360107	Coiled-coil domain containing 105.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.948
CCDC105	EFHC2	ENSP00000292574	ENSP00000404232	Coiled-coil domain containing 105.	EF-hand domain-containing family member C2; EF-hand domain containing 2.	0.966
CCDC105	FAM166A	ENSP00000292574	ENSP00000344729	Coiled-coil domain containing 105.	Protein FAM166A; Family with sequence similarity 166 member A.	0.963
CCDC105	PACRG	ENSP00000292574	ENSP00000337946	Coiled-coil domain containing 105.	Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	0.907
CCDC105	SPAG8	ENSP00000292574	ENSP00000340982	Coiled-coil domain containing 105.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.960
CCDC105	TEKT2	ENSP00000292574	ENSP00000207457	Coiled-coil domain containing 105.	Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.	0.962
CCDC105	TEKT5	ENSP00000292574	ENSP00000283025	Coiled-coil domain containing 105.	Tektin-5; May be a structural component of the sperm flagellum.	0.970
EFCAB3	CCDC105	ENSP00000403932	ENSP00000292574	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	Coiled-coil domain containing 105.	0.868
EFCAB3	EFCAB6	ENSP00000403932	ENSP00000262726	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.	0.924
EFCAB3	EFHB	ENSP00000403932	ENSP00000295824	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.967
EFCAB3	EFHC1	ENSP00000403932	ENSP00000360107	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.926
EFCAB3	EFHC2	ENSP00000403932	ENSP00000404232	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	EF-hand domain-containing family member C2; EF-hand domain containing 2.	0.934
EFCAB3	FAM166A	ENSP00000403932	ENSP00000344729	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	Protein FAM166A; Family with sequence similarity 166 member A.	0.922
EFCAB3	PACRG	ENSP00000403932	ENSP00000337946	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	0.867
EFCAB3	SPAG8	ENSP00000403932	ENSP00000340982	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.867
EFCAB3	TEKT2	ENSP00000403932	ENSP00000207457	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.	0.883
EFCAB3	TEKT5	ENSP00000403932	ENSP00000283025	EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.	Tektin-5; May be a structural component of the sperm flagellum.	0.912