node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf74 | C11orf91 | ENSP00000403937 | ENSP00000368296 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. | 0.434 |
C11orf74 | C14orf119 | ENSP00000403937 | ENSP00000322238 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119. | 0.447 |
C11orf74 | IFT122 | ENSP00000403937 | ENSP00000296266 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). | 0.955 |
C11orf74 | IFT140 | ENSP00000403937 | ENSP00000406012 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). | 0.844 |
C11orf74 | IFT43 | ENSP00000403937 | ENSP00000238628 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. | 0.943 |
C11orf74 | OR52R1 | ENSP00000403937 | ENSP00000485292 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Olfactory receptor 52R1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.582 |
C11orf74 | PLK1 | ENSP00000403937 | ENSP00000300093 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.420 |
C11orf74 | UBE2S | ENSP00000403937 | ENSP00000264552 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] | 0.471 |
C11orf74 | WDR19 | ENSP00000403937 | ENSP00000382717 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | WD repeat-containing protein 19; As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport (By similarity). | 0.922 |
C11orf74 | WDR35 | ENSP00000403937 | ENSP00000314444 | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis. | 0.841 |
C11orf91 | C11orf74 | ENSP00000368296 | ENSP00000403937 | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91. | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | 0.434 |
C14orf119 | C11orf74 | ENSP00000322238 | ENSP00000403937 | Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119. | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | 0.447 |
IFT122 | C11orf74 | ENSP00000296266 | ENSP00000403937 | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | 0.955 |
IFT122 | IFT140 | ENSP00000296266 | ENSP00000406012 | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). | 0.999 |
IFT122 | IFT43 | ENSP00000296266 | ENSP00000238628 | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). | Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. | 0.999 |
IFT122 | WDR19 | ENSP00000296266 | ENSP00000382717 | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). | WD repeat-containing protein 19; As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport (By similarity). | 0.999 |
IFT122 | WDR35 | ENSP00000296266 | ENSP00000314444 | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). | WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis. | 0.999 |
IFT140 | C11orf74 | ENSP00000406012 | ENSP00000403937 | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). | Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. | 0.844 |
IFT140 | IFT122 | ENSP00000406012 | ENSP00000296266 | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). | 0.999 |
IFT140 | IFT43 | ENSP00000406012 | ENSP00000238628 | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity). | Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. | 0.999 |