node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf201 | CEP170B | ENSP00000420610 | ENSP00000404151 | Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201. | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | 0.480 |
CAMSAP2 | CEP170B | ENSP00000236925 | ENSP00000404151 | Calmodulin-regulated spectrin-associated protein 2; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus- ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In addition, it also reduces the velocity of microtubul [...] | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | 0.474 |
CAMSAP2 | KIF2A | ENSP00000236925 | ENSP00000385000 | Calmodulin-regulated spectrin-associated protein 2; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus- ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In addition, it also reduces the velocity of microtubul [...] | Kinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. | 0.420 |
CEP170 | CEP170B | ENSP00000355500 | ENSP00000404151 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Belongs to the CEP170 family. | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | 0.537 |
CEP170 | KIF2A | ENSP00000355500 | ENSP00000385000 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Belongs to the CEP170 family. | Kinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. | 0.962 |
CEP170 | KIF2B | ENSP00000355500 | ENSP00000268919 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Belongs to the CEP170 family. | Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression. | 0.829 |
CEP170B | C6orf201 | ENSP00000404151 | ENSP00000420610 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201. | 0.480 |
CEP170B | CAMSAP2 | ENSP00000404151 | ENSP00000236925 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Calmodulin-regulated spectrin-associated protein 2; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus- ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In addition, it also reduces the velocity of microtubul [...] | 0.474 |
CEP170B | CEP170 | ENSP00000404151 | ENSP00000355500 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Belongs to the CEP170 family. | 0.537 |
CEP170B | CWF19L2 | ENSP00000404151 | ENSP00000282251 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | 0.556 |
CEP170B | INTS9 | ENSP00000404151 | ENSP00000429065 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS9 subfamily. | 0.460 |
CEP170B | KIF2A | ENSP00000404151 | ENSP00000385000 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Kinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. | 0.586 |
CEP170B | KIF2B | ENSP00000404151 | ENSP00000268919 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression. | 0.610 |
CEP170B | RAB39A | ENSP00000404151 | ENSP00000322594 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Ras-related protein Rab-39A; Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K. May be involved in multiple neurite formation (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.498 |
CEP170B | RAI14 | ENSP00000404151 | ENSP00000427123 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Ankycorbin; Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood- testis barrier. | 0.453 |
CEP170B | SPATA7 | ENSP00000404151 | ENSP00000377176 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Spermatogenesis-associated protein 7; Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). | 0.442 |
CWF19L2 | CEP170B | ENSP00000282251 | ENSP00000404151 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | 0.556 |
CWF19L2 | INTS9 | ENSP00000282251 | ENSP00000429065 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS9 subfamily. | 0.524 |
CWF19L2 | RAB39A | ENSP00000282251 | ENSP00000322594 | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | Ras-related protein Rab-39A; Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K. May be involved in multiple neurite formation (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.613 |
INTS9 | CEP170B | ENSP00000429065 | ENSP00000404151 | Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS9 subfamily. | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | 0.460 |