ARL17B protein (human) - STRING interaction network

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Score

ARL17B

ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B. (181 aa)

Predicted Functional Partners:

KANSL1

0.768

LRRC37A2

0.744

LRRC37A

0.737

LRRC37A3

0.737

POTEB

0.638

ARHGAP27

0.560

ITSN2

0.536

ITSN1

0.535

PLEKHM1

0.482

SPPL2C

0.480

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP27	ARL17B	ENSP00000403323	ENSP00000460539	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	0.560
ARHGAP27	KANSL1	ENSP00000403323	ENSP00000387393	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	KAT8 regulatory NSL complex subunit 1; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.	0.580
ARHGAP27	LRRC37A	ENSP00000403323	ENSP00000326324	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	Leucine-rich repeat-containing protein 37A; Leucine rich repeat containing 37A.	0.507
ARHGAP27	LRRC37A2	ENSP00000403323	ENSP00000459551	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2.	0.542
ARHGAP27	LRRC37A3	ENSP00000403323	ENSP00000464535	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	Leucine-rich repeat-containing protein 37A3; Leucine rich repeat containing 37 member A3.	0.506
ARHGAP27	PLEKHM1	ENSP00000403323	ENSP00000389913	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distributi [...]	0.604
ARHGAP27	SPPL2C	ENSP00000403323	ENSP00000332488	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	Signal peptide peptidase-like 2C; Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.	0.480
ARL17B	ARHGAP27	ENSP00000460539	ENSP00000403323	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	0.560
ARL17B	ITSN1	ENSP00000460539	ENSP00000370719	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...]	0.535
ARL17B	ITSN2	ENSP00000460539	ENSP00000347244	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.	0.536
ARL17B	KANSL1	ENSP00000460539	ENSP00000387393	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	KAT8 regulatory NSL complex subunit 1; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.	0.768
ARL17B	LRRC37A	ENSP00000460539	ENSP00000326324	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Leucine-rich repeat-containing protein 37A; Leucine rich repeat containing 37A.	0.737
ARL17B	LRRC37A2	ENSP00000460539	ENSP00000459551	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2.	0.744
ARL17B	LRRC37A3	ENSP00000460539	ENSP00000464535	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Leucine-rich repeat-containing protein 37A3; Leucine rich repeat containing 37 member A3.	0.737
ARL17B	PLEKHM1	ENSP00000460539	ENSP00000389913	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distributi [...]	0.482
ARL17B	POTEB	ENSP00000460539	ENSP00000457689	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	POTE ankyrin domain family member B.	0.638
ARL17B	SPPL2C	ENSP00000460539	ENSP00000332488	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	Signal peptide peptidase-like 2C; Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.	0.480
ITSN1	ARL17B	ENSP00000370719	ENSP00000460539	Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...]	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	0.535
ITSN1	ITSN2	ENSP00000370719	ENSP00000347244	Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...]	Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.	0.664
ITSN2	ARL17B	ENSP00000347244	ENSP00000460539	Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.	ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.	0.536